Reactome | Nicotinate metabolism

Schema > Pathway > Entries

Nicotinate metabolism Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099697
displayName	Nicotinate metabolism
eventOf	[Pathway:R-MMU-196849] Metabolism of water-soluble vitamins and cofactors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3132622] nicotinate metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-197268] QPRT transfers PRIB to QUIN to form NAMN - Mus musculus [Reaction:R-MMU-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus [Reaction:R-MMU-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Mus musculus [Reaction:R-MMU-8869603] SLC22A13 exchanges extracellular NCA for cytosolic urate - Mus musculus [Reaction:R-MMU-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Mus musculus [Reaction:R-MMU-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN - Mus musculus [Reaction:R-MMU-8869606] NMRK1 phosphorylates NAR to yield NAMN - Mus musculus [Reaction:R-MMU-8869607] NMRK2 phosphorylates NAR to yield NAMN - Mus musculus [Reaction:R-MMU-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ - Mus musculus [Reaction:R-MMU-8869633] NMRK1 phosphorylates NR to yield NMN - Mus musculus [Reaction:R-MMU-8869627] NMRK2 phosphorylates NR to yield NMN - Mus musculus [Reaction:R-MMU-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - Mus musculus [Reaction:R-MMU-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus [Reaction:R-MMU-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Mus musculus [Reaction:R-MMU-8940070] NT5E:Zn2+ hydrolyses NAD+ - Mus musculus [Reaction:R-MMU-8940074] NT5E:Zn2+ hydrolyses NMN - Mus musculus [Reaction:R-MMU-8870346] BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose - Mus musculus [Reaction:R-MMU-8938076] CD38 hydrolyses NAD+ to NAM and ADP-ribose - Mus musculus [Reaction:R-MMU-9938195] SLC25A51 mediates mitochondrial uptake of NAD+ - Mus musculus [Reaction:R-MMU-8955030] NADK2 dimer phosphorylates NAD+ to NADP+ - Mus musculus [Reaction:R-MMU-197250] NAMPT transfers PRIB to NAM to form NAMN - Mus musculus [Reaction:R-MMU-5359451] NNMT transfers CH3 from SAM to NAM to form MNA - Mus musculus [Reaction:R-MMU-6806966] APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX - Mus musculus [Reaction:R-MMU-6806967] CARKD dehydrates S-NAD(P)HX to NADPH - Mus musculus [Reaction:R-MMU-6809287] NUDT12 hydrolyses NADH to NMNH - Mus musculus [Reaction:R-MMU-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Mus musculus
inferredFrom	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Nicotinate metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-196807
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196849] Metabolism of water-soluble vitamins and cofactors
(hasEncapsulatedEvent)	[Pathway:R-MMU-71240] Tryptophan catabolism
(inferredTo)	[Pathway:R-HSA-196807] Nicotinate metabolism

© 2026 Reactome

Cite Us!