Reactome | NMRK2 phosphorylates NR to yield NMN

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NMRK2 phosphorylates NR to yield NMN Show undefined attributes

authored	[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
catalystActivity	[CatalystActivity:8869614] ribosylnicotinamide kinase activity of NMRK2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643117] ribosylnicotinamide kinase activity of NMRK2 [cytosol] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
crossReference	[DatabaseIdentifier:12667999] RHEA:14018 [DatabaseIdentifier:9938190] RHEA:14018
dbId	8869627
displayName	NMRK2 phosphorylates NR to yield NMN
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-8869377] NR [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8869355] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans [LiteratureReference:9938175] NAD⁺ metabolism and its roles in cellular processes during ageing [LiteratureReference:8869621] A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation [LiteratureReference:8869378] Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation [LiteratureReference:8869366] The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis [LiteratureReference:8869349] Nicotinamide riboside kinase structures reveal new pathways to NAD+
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	NMRK2 phosphorylates NR to yield NMN beta-nicotinamide D-riboside + ATP => beta-nicotinamide D-ribonucleotide + ADP + H(+) NR + ATP(4-) => NMN + ADP(3-) + H+
orthologousEvent	[Reaction:R-SCE-8869627] NMRK2 phosphorylates NR to yield NMN - Saccharomyces cerevisiae [Reaction:R-SPO-8869627] NMRK2 phosphorylates NR to yield NMN - Schizosaccharomyces pombe [Reaction:R-DDI-8869627] NMRK2 phosphorylates NR to yield NMN - Dictyostelium discoideum [Reaction:R-DME-8869627] NMRK2 phosphorylates NR to yield NMN - Drosophila melanogaster [Reaction:R-GGA-8869627] NMRK2 phosphorylates NR to yield NMN - Gallus gallus [Reaction:R-XTR-8869627] NMRK2 phosphorylates NR to yield NMN - Xenopus tropicalis [Reaction:R-DRE-8869627] NMRK2 phosphorylates NR to yield NMN - Danio rerio [Reaction:R-SSC-8869627] NMRK2 phosphorylates NR to yield NMN - Sus scrofa [Reaction:R-BTA-8869627] NMRK2 phosphorylates NR to yield NMN - Bos taurus [Reaction:R-MMU-8869627] NMRK2 phosphorylates NR to yield NMN - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-8869353] NMN [cytosol]
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8869627
summation	[Summation:8869612] Cytosolic NMRK2 (nicotinamide riboside kinase 2), localized ...
updateTrackers	[UpdateTracker:9777631] Update Tracker - [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN - v70:[add_removeInput, add_removeOutput] [UpdateTracker:9939666] Update Tracker - [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN - v92:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9777631] Update Tracker - [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN - v70:[add_removeInput, add_removeOutput] [UpdateTracker:9939666] Update Tracker - [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN - v92:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-HSA-8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+

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