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Reaction
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Entries
NMRK1 phosphorylates NAR to yield NAMN
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authored
[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
catalystActivity
[CatalystActivity:8869636] nicotinate riboside kinase activity of NMRK1 [cytosol]
catalystActivityReference
[CatalystActivityReference:9643505] ribosylnicotinate kinase activity of NMRK1 [cytosol] Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8869619] D'Eustachio, Peter, 2016-05-05
crossReference
[DatabaseIdentifier:12667997] RHEA:25569
[DatabaseIdentifier:9937914] RHEA:25569
dbId
8869606
displayName
NMRK1 phosphorylates NAR to yield NAMN
edited
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf
[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
[Reaction:R-HSA-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-8869365] NAR [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8869378] Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation
[LiteratureReference:8869366] The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis
[LiteratureReference:8869349] Nicotinamide riboside kinase structures reveal new pathways to NAD+
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
NMRK1 phosphorylates NAR to yield NAMN
beta-D-ribosylnicotinate + ATP => nicotinate beta-D-ribonucleotide + ADP + H(+)
NAR + ATP(4-) => NAMN + ADP(3-) + H+
orthologousEvent
[Reaction:R-RNO-8869606] NMRK1 phosphorylates NAR to yield NAMN - Rattus norvegicus
[Reaction:R-SCE-8869606] NMRK1 phosphorylates NAR to yield NAMN - Saccharomyces cerevisiae
[Reaction:R-SPO-8869606] NMRK1 phosphorylates NAR to yield NAMN - Schizosaccharomyces pombe
[Reaction:R-DDI-8869606] NMRK1 phosphorylates NAR to yield NAMN - Dictyostelium discoideum
[Reaction:R-DME-8869606] NMRK1 phosphorylates NAR to yield NAMN - Drosophila melanogaster
[Reaction:R-GGA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Gallus gallus
[Reaction:R-XTR-8869606] NMRK1 phosphorylates NAR to yield NAMN - Xenopus tropicalis
[Reaction:R-DRE-8869606] NMRK1 phosphorylates NAR to yield NAMN - Danio rerio
[Reaction:R-SSC-8869606] NMRK1 phosphorylates NAR to yield NAMN - Sus scrofa
[Reaction:R-BTA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Bos taurus
[Reaction:R-CFA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Canis familiaris
[Reaction:R-MMU-8869606] NMRK1 phosphorylates NAR to yield NAMN - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-8869359] NAMN [cytosol]
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2016-12-12
reviewStatus
[ReviewStatus:9821385] four stars
reviewed
[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
revised
[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8869606
summation
[Summation:8869605] Cytosolic NMRK1 (nicotinamide riboside kinase 1) (Nikiforov ...
updateTrackers
[UpdateTracker:9777634] Update Tracker - [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9939833] Update Tracker - [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN - v92:[add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9777634] Update Tracker - [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN - v70:[add_removeInput, add_removeOutput]
[UpdateTracker:9939833] Update Tracker - [Reaction:8869606] NMRK1 phosphorylates NAR to yield NAMN - v92:[add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-196807] Nicotinate metabolism
(precedingEvent)
[Reaction:R-HSA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
[Reaction:R-HSA-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
[Reaction:R-HSA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD
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