Reactome | NT5E:Zn2+ hydrolyses NAD+

Schema > Reaction > Entries

NT5E:Zn2+ hydrolyses NAD+ Show undefined attributes

authored	[InstanceEdit:8940071] Jassal, Bijay, 2016-09-23
catalystActivity	[CatalystActivity:109273] 5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643223] 5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane] Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8940071] Jassal, Bijay, 2016-09-23
dbId	8940070
displayName	NT5E:Zn2+ hydrolyses NAD+
edited	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
eventOf	[Pathway:R-HSA-196807] Nicotinate metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-352330] NAD+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8940072] The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism [LiteratureReference:500106] Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form [LiteratureReference:109263] 5'-nucleotidase: molecular structure and functional aspects
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NT5E:Zn2+ hydrolyses NAD+
orthologousEvent	[Reaction:R-RNO-8940070] NT5E:Zn2+ hydrolyses NAD+ - Rattus norvegicus [Reaction:R-DME-8940070] NT5E:Zn2+ hydrolyses NAD+ - Drosophila melanogaster [Reaction:R-GGA-8940070] NT5E:Zn2+ hydrolyses NAD+ - Gallus gallus [Reaction:R-XTR-8940070] NT5E:Zn2+ hydrolyses NAD+ - Xenopus tropicalis [Reaction:R-DRE-8940070] NT5E:Zn2+ hydrolyses NAD+ - Danio rerio [Reaction:R-SSC-8940070] NT5E:Zn2+ hydrolyses NAD+ - Sus scrofa [Reaction:R-BTA-8940070] NT5E:Zn2+ hydrolyses NAD+ - Bos taurus [Reaction:R-CFA-8940070] NT5E:Zn2+ hydrolyses NAD+ - Canis familiaris [Reaction:R-MMU-8940070] NT5E:Zn2+ hydrolyses NAD+ - Mus musculus
output	[SimpleEntity:R-ALL-109275] AMP [extracellular region] 2 × [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-8940067] NMN [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
revised	[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8940070
summation	[Summation:8940080] 5'-nucleotidase (NT5E, CD73) hydrolyzes NAD+ to yield beta-n...
updateTrackers	[UpdateTracker:9939810] Update Tracker - [Reaction:8940070] NT5E:Zn2+ hydrolyses NAD+ - v92:[modifyText, removeOutput]

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(updatedInstance)	[UpdateTracker:9939810] Update Tracker - [Reaction:8940070] NT5E:Zn2+ hydrolyses NAD+ - v92:[modifyText, removeOutput]
(hasEvent)	[Pathway:R-HSA-196807] Nicotinate metabolism