Reactome | Signaling by cytosolic FGFR1 fusion mutants

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Signaling by cytosolic FGFR1 fusion mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839118] Rothfels, K, 2011-10-27
dbId	1839117
disease	[Disease:1247687] chronic myeloid leukemia [Disease:1604519] subacute leukemia [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:2317476] acute lymphocytic leukemia
displayName	Signaling by cytosolic FGFR1 fusion mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1839031] Dimerization of cytosolic FGFR1 fusion proteins - Homo sapiens [Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens [Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 - Homo sapiens [Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA - Homo sapiens [Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 - Homo sapiens [Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2 - Homo sapiens [Reaction:R-HSA-1839110] p-BCR-p-FGFR1 phosphorylates GAB2 - Homo sapiens [Reaction:R-HSA-1839114] BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 - Homo sapiens [Reaction:R-HSA-1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. - Homo sapiens [Reaction:R-HSA-1839112] Phosphorylation of STAT5 by cytosolic FGFR1 fusions - Homo sapiens [Reaction:R-HSA-1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review [LiteratureReference:1679950] Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome [LiteratureReference:1679948] Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation [LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways [LiteratureReference:1606521] The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11) [LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1834981] ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5 [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by cytosolic FGFR1 fusion mutants
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1839117
summation	[Summation:1986613] 8p11 myeloproliferative syndrome (EMS) is an aggressive diso...

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[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation

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