Reactome | FGFR1 mutant receptor activation

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FGFR1 mutant receptor activation Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1839123] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	1839124
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR1 mutant receptor activation
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-1839120] Signaling by FGFR1 amplification mutants - Homo sapiens [Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens [Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens [Pathway:R-HSA-8853336] Signaling by plasma membrane FGFR1 fusions - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FGFR1 mutant receptor activation
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
revised	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1839124
summation	[Summation:5691449] The FGFR1 gene has been shown to be subject to activating mu...
updateTrackers	[UpdateTracker:9786623] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v49:[updateContainedPathway] [UpdateTracker:9784988] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v52:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778495] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v68:[updateIndirectRLE] [UpdateTracker:9783661] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v56:[addHasEvent] [UpdateTracker:9784593] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference, updateContainedPathway]

Referrals

(updatedInstance)

[UpdateTracker:9786623] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v49:[updateContainedPathway]
[UpdateTracker:9784988] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v52:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778495] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v68:[updateIndirectRLE]
[UpdateTracker:9783661] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v56:[addHasEvent]
[UpdateTracker:9784593] Update Tracker - [Pathway:1839124] FGFR1 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference, updateContainedPathway]

(hasEvent)

[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease

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