Reactome | FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3

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FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1888195] protein tyrosine kinase activity of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1888194] Rothfels, K, 2011-10-31
crossReference	[DatabaseIdentifier:12020830] Mondo:0002582
dbId	1888198
disease	[Disease:1500689] cancer [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:1604519] subacute leukemia [Disease:2317476] acute lymphocytic leukemia
displayName	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654512] gain_of_function of FGFR1OP-p-FGFR1 fusion mutant dimer [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-1112559] STAT1, STAT3 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways [LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
maxDepth	1
modified	[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023-04-07
name	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-1112571] p-Y701-STAT1, p-Y705-STAT3 [cytosol]
precedingEvent	[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1888198
summation	[Summation:1888191] Expression of FGFR1OP-FGFR1 in both Ba/F3 and Cos-1 cells le...
updateTrackers	[UpdateTracker:9778174] Update Tracker - [Reaction:1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 - v68:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9778174] Update Tracker - [Reaction:1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 - v68:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

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