Reactome | Phosphorylation of BCR moiety of BCR-FGFR1

Schema > Reaction > Entries

Phosphorylation of BCR moiety of BCR-FGFR1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839068] protein tyrosine kinase activity of BCR-p-FGFR1 fusion mutant dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839070] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020786] Mondo:0011996
dbId	1839067
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	Phosphorylation of BCR moiety of BCR-FGFR1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654534] gain_of_function of BCR-p-FGFR1 fusion mutant dimer [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 - Homo sapiens [Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1838980] BCR-p-FGFR1 fusion mutant dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of BCR moiety of BCR-FGFR1
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
precedingEvent	[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839067
summation	[Summation:1839069] Unique among FGFR1 fusion proteins, which generally give ris...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 [Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2
(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

Cite Us!