Reactome | Phosphorylation of STAT5 by cytosolic FGFR1 fusions

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Phosphorylation of STAT5 by cytosolic FGFR1 fusions Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839025] protein tyrosine kinase activity of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839111] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020830] Mondo:0002582
dbId	1839112
disease	[Disease:1500689] cancer [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:1604519] subacute leukemia [Disease:2317476] acute lymphocytic leukemia
displayName	Phosphorylation of STAT5 by cytosolic FGFR1 fusions
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:9630091] gain_of_function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-452094] STAT5A,STAT5B [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome [LiteratureReference:1834981] ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5 [LiteratureReference:1606521] The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11) [LiteratureReference:1834978] Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1
maxDepth	1
modified	[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023-04-07
name	Phosphorylation of STAT5 by cytosolic FGFR1 fusions
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-507929] p-STAT5A, p-STAT5B [cytosol]
precedingEvent	[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839112
summation	[Summation:1839087] Activation of a subset of FGFR1-fusions (ZMYM2, BCR, FGFR1OP...

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[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

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