Reactome | p-BCR-pFGFR1 binds GRB2:GAB2

Schema > Reaction > Entries

p-BCR-pFGFR1 binds GRB2:GAB2 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839096] Rothfels, K, 2011-10-27
dbId	1839095
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	p-BCR-pFGFR1 binds GRB2:GAB2
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654559] gain_of_function of pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1839110] p-BCR-p-FGFR1 phosphorylates GAB2 - Homo sapiens
input	[Complex:R-HSA-912522] GRB2:GAB2 [cytosol] [Complex:R-HSA-1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1834975] Critical role for Gab2 in transformation by BCR/ABL
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-BCR-pFGFR1 binds GRB2:GAB2
output	[Complex:R-HSA-1839045] pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
precedingEvent	[Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839095
summation	[Summation:1839076] Proliferation of BCR-FGFR1 fusion proteins is blocked by tre...

Referrals

(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
(precedingEvent)	[Reaction:R-HSA-1839110] p-BCR-p-FGFR1 phosphorylates GAB2