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Schema
>
BlackBoxEvent
>
Entries
Cytosolic FGFR1 fusion proteins bind PIK3R1
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:1839079] Rothfels, K, 2011-10-27
dbId
1839078
disease
[Disease:1500689] cancer
displayName
Cytosolic FGFR1 fusion proteins bind PIK3R1
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5654506] gain_of_function of cytosolic p-FGFR1 fusion mutant dimers [cytosol]
eventOf
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA - Homo sapiens
input
[CandidateSet:R-HSA-1839020] cytosolic p-FGFR1 fusion mutant dimers [cytosol]
[EntityWithAccessionedSequence:R-HSA-74789] PIK3R1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1679950] Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome
[LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Cytosolic FGFR1 fusion proteins bind PIK3R1
output
[Complex:R-HSA-1839052] p-FGFR1 fusion mutant dimers:PIK3R1 [cytosol]
precedingEvent
[Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 - Homo sapiens
[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-1839078
summation
[Summation:1839077] Activation of the PI3K signaling pathway has been demonstrat...
Referrals
(hasEvent)
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
(precedingEvent)
[Reaction:R-HSA-1839080] Activated cytosolic FGFR1 fusions bind PIK3CA
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