Reactome | Phosphorylation of cytosolic FGFR1 fusion dimers

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Phosphorylation of cytosolic FGFR1 fusion dimers Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839066] protein tyrosine kinase activity of cytosolic FGFR1 fusion mutant dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839064] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1839065
disease	[Disease:1500689] cancer
displayName	Phosphorylation of cytosolic FGFR1 fusion dimers
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654536] gain_of_function of cytosolic FGFR1 fusion mutant dimers [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 - Homo sapiens [Reaction:R-HSA-1839112] Phosphorylation of STAT5 by cytosolic FGFR1 fusions - Homo sapiens [Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 - Homo sapiens [Reaction:R-HSA-1839094] Activated FGFR1 mutants and fusions bind PLCG1 - Homo sapiens [BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-1839026] cytosolic FGFR1 fusion mutant dimers [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1606519] 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes [LiteratureReference:1679950] Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome [LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1637873] Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome [LiteratureReference:1604430] FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33) [LiteratureReference:1604432] Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13) [LiteratureReference:1679948] Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of cytosolic FGFR1 fusion dimers
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-1839020] cytosolic p-FGFR1 fusion mutant dimers [cytosol]
precedingEvent	[Reaction:R-HSA-1839031] Dimerization of cytosolic FGFR1 fusion proteins - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839065
summation	[Summation:1839056] After ligand-independent dimerization, FGFR1 fusions are tra...

Referrals

(precedingEvent)	[Reaction:R-HSA-1888198] FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 [Reaction:R-HSA-1839112] Phosphorylation of STAT5 by cytosolic FGFR1 fusions [BlackBoxEvent:R-HSA-1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 [Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 [Reaction:R-HSA-1839094] Activated FGFR1 mutants and fusions bind PLCG1
(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants

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