Reactome | p-BCR-p-FGFR1 phosphorylates GAB2

Schema > Reaction > Entries

p-BCR-p-FGFR1 phosphorylates GAB2 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839105] protein tyrosine kinase activity of pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839109] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020786] Mondo:0011996
dbId	1839110
disease	[Disease:1500689] cancer [Disease:1247687] chronic myeloid leukemia
displayName	p-BCR-p-FGFR1 phosphorylates GAB2
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654556] gain_of_function of pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
eventOf	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-1839114] BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1839045] pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1604429] Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [LiteratureReference:1834975] Critical role for Gab2 in transformation by BCR/ABL [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-BCR-p-FGFR1 phosphorylates GAB2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1839047] pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol]
precedingEvent	[Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839110
summation	[Summation:2054050] Recruitment of GAB2 to the BCR-FGFR1 fusion protein results ...

Referrals

(hasEvent)	[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
(precedingEvent)	[Reaction:R-HSA-1839114] BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1

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