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Entries
Dimerization of cytosolic FGFR1 fusion proteins
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:1839030] Rothfels, K, 2011-10-27
dbId
1839031
disease
[Disease:1500689] cancer
displayName
Dimerization of cytosolic FGFR1 fusion proteins
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5654483] gain_of_function of cytosolic FGFR1 fusion mutants [cytosol]
eventOf
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation - Homo sapiens
[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers - Homo sapiens
input
2 ×
[CandidateSet:R-HSA-1839029] cytosolic FGFR1 fusion mutants [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1602278] De-regulated FGF receptors as therapeutic targets in cancer
[LiteratureReference:1602282] LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome
[LiteratureReference:1604432] Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)
[LiteratureReference:1602276] Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome
[LiteratureReference:1602279] FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome
[LiteratureReference:1602283] The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
[LiteratureReference:1604430] FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1606444] Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
[LiteratureReference:1606447] The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1
[LiteratureReference:1606521] The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
[LiteratureReference:1606519] 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
[LiteratureReference:1606523] The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1
[LiteratureReference:1679948] Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation
[LiteratureReference:1834979] ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain
[LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review
[LiteratureReference:2085570] Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Dimerization of cytosolic FGFR1 fusion proteins
output
[CandidateSet:R-HSA-1839026] cytosolic FGFR1 fusion mutant dimers [cytosol]
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1839031
summation
[Summation:1637869] 8p11 myeloproliferative syndrome (EMS) is a myeloproliferati...
Referrals
(hasEvent)
[Pathway:R-HSA-1839117] Signaling by cytosolic FGFR1 fusion mutants
(precedingEvent)
[Reaction:R-HSA-1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation
[Reaction:R-HSA-1839065] Phosphorylation of cytosolic FGFR1 fusion dimers
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