Reactome | p-2S-SMAD2,3:SMAD4 [nucleoplasm]

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p-2S-SMAD2,3:SMAD4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-1225870] SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] - Homo sapiens [Complex:R-HSA-9823969] p-2S-SMAD2,3:GATA6-AS1 lncRNA:GATA6 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] - Homo sapiens [Complex:R-HSA-9823985] EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9756966] p-2S-SMAD2,3:SMAD4:TRIM33:CTNNB1:FOXH1:SMAD3:EOMES:TBPL2:GSC gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element - Homo sapiens [Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Homo sapiens [Reaction:R-HSA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Homo sapiens [Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Homo sapiens [Reaction:R-HSA-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Homo sapiens [Reaction:R-HSA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Homo sapiens [BlackBoxEvent:R-HSA-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling - Homo sapiens [Reaction:R-HSA-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens [Reaction:R-HSA-9736992] p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter - Homo sapiens [Reaction:R-HSA-9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene - Homo sapiens [Reaction:R-HSA-9756948] p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene - Homo sapiens [Reaction:R-HSA-9823959] SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene - Homo sapiens [Reaction:R-NUL-9625758] FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter - Homo sapiens [Reaction:R-HSA-9625749] FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter - Homo sapiens [Reaction:R-HSA-9625510] FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter - Homo sapiens [Reaction:R-HSA-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 - Homo sapiens [Reaction:R-HSA-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Homo sapiens [Reaction:R-HSA-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 - Homo sapiens [Reaction:R-HSA-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 - Homo sapiens [Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens [Reaction:R-HSA-9823966] EOMES, SMAD2,3, MIXL1 bind the GSC gene - Homo sapiens [Reaction:R-HSA-9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene - Homo sapiens [Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene - Homo sapiens [Reaction:R-HSA-9756724] p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene - Homo sapiens [Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene - Homo sapiens [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
created	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35
dbId	173511
displayName	p-2S-SMAD2,3:SMAD4 [nucleoplasm]
hasMember	[Complex:R-HSA-8878153] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9736929] p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Mus musculus [DefinedSet:R-RNO-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Rattus norvegicus [DefinedSet:R-CFA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Canis familiaris [DefinedSet:R-BTA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Bos taurus [Complex:R-SSC-8878153] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] - Sus scrofa [GenomeEncodedEntity:R-DRE-173511] Ghost homologue of p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Danio rerio [Complex:R-XTR-206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] - Xenopus tropicalis [DefinedSet:R-GGA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Gallus gallus [DefinedSet:R-DME-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Drosophila melanogaster [DefinedSet:R-CEL-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Caenorhabditis elegans
maxDepth	3
modified	[InstanceEdit:9736935] Orlic-Milacic, Marija, 2021-07-15
name	p-2S-SMAD2,3:SMAD4 Phospho-R-SMAD:CO-SMAD complex
positivelyRegulates	[PositiveGeneExpressionRegulation:9733201] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens [Reaction:R-NUL-2186755] Ubiquitination of SKI/SKIL by Rnf111 - Homo sapiens [Reaction:R-HSA-2186747] Ubiquitination of SKI/SKIL by RNF111/SMURF2 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-173511

Referrals

(hasComponent)	[Complex:R-HSA-1225870] SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] [Complex:R-HSA-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] [Complex:R-HSA-9756966] p-2S-SMAD2,3:SMAD4:TRIM33:CTNNB1:FOXH1:SMAD3:EOMES:TBPL2:GSC gene [nucleoplasm] [Complex:R-HSA-9823985] EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] [Complex:R-HSA-9823975] EOMES:p-2S-SMAD2,3:SMAD4:GATA6:CXCR4 gene [nucleoplasm] [Complex:R-HSA-9823834] p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] [Complex:R-HSA-9756735] p-2S-SMAD2,3:TRIM33:p-2S-SMAD2,3:SMAD4:CTNNB1:FOXH1:EOMES:TBPL2:MIXL1 gene [nucleoplasm] [Complex:R-HSA-9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] [Complex:R-HSA-9823969] p-2S-SMAD2,3:GATA6-AS1 lncRNA:GATA6 gene [nucleoplasm] [Complex:R-HSA-9823963] EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] [Complex:R-NUL-9625760] FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:Trim63 gene [nucleoplasm] [Complex:R-HSA-9625757] FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm] [Complex:R-HSA-9625499] FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm] [Complex:R-HSA-2127250] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] [Complex:R-HSA-870446] p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] [Complex:R-HSA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] [Complex:R-HSA-2106580] WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-HSA-9618006] FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] [Complex:R-HSA-9617984] FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] [Complex:R-HSA-2187302] p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] [Complex:R-HSA-2186606] p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] [Complex:R-HSA-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] [Complex:R-HSA-2187392] p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] [Complex:R-HSA-2186642] p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] [Complex:R-HSA-9736993] p-2S-SMAD2,3:SMAD4:JUNB gene [nucleoplasm] [Complex:R-HSA-9754475] p-2S-SMAD2,3:SMAD4:CTNNB1:TBPL2:FOXH1:SMAD3:POU5F1:NANOG:EOMES gene [nucleoplasm]
(input)	[Reaction:R-HSA-1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element [Reaction:R-HSA-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Reaction:R-HSA-9756948] p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene [Reaction:R-HSA-9823966] EOMES, SMAD2,3, MIXL1 bind the GSC gene [Reaction:R-HSA-9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene [Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene [Reaction:R-HSA-9756724] p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene [Reaction:R-HSA-9823959] SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene [Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene [Reaction:R-NUL-9625758] FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter [Reaction:R-HSA-9625749] FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter [Reaction:R-HSA-9625510] FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter [Reaction:R-HSA-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Reaction:R-HSA-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus [Reaction:R-HSA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling [Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Reaction:R-HSA-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 [Reaction:R-HSA-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 [Reaction:R-HSA-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Reaction:R-HSA-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-HSA-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 [BlackBoxEvent:R-HSA-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling [Reaction:R-HSA-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-HSA-9736992] p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter [Reaction:R-HSA-9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene
(output)	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Reaction:R-HSA-2186747] Ubiquitination of SKI/SKIL by RNF111/SMURF2 [Reaction:R-NUL-2186755] Ubiquitination of SKI/SKIL by Rnf111
(activeUnit)	[PositiveGeneExpressionRegulation:9625768] Positive gene expression regulation by 'FOXO1,FOXO3:p-2S-SMAD2/3:SMAD4:TRIM63 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9733201] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-2187299] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4:JUNB gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9625537] Positive gene expression regulation by 'FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm]'
(regulator)	[PositiveGeneExpressionRegulation:9733201] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4 [nucleoplasm]'

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