Reactome | EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]

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EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823972] May, Bruce, 2023-01-13
dbId	9823963
displayName	EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-9827604] DEANR1 lncRNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9796194] FOXA2 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452902] GATA6 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452976] TBXT [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation [LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:9796288] The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression
maxDepth	4
modified	[InstanceEdit:9827632] May, Bruce, 2023-01-31
name	EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:9823997] Positive gene expression regulation by 'EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9823963
updateTrackers	[UpdateTracker:9906103] Update Tracker - [Complex:9823963] EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] - v86:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9906103] Update Tracker - [Complex:9823963] EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] - v86:[updateContainedComponent]
(output)	[Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene
(regulator)	[PositiveGeneExpressionRegulation:9823997] Positive gene expression regulation by 'EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]'

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