Reactome | p-2S-SMAD2,3:SMAD4 [nucleoplasm]

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p-2S-SMAD2,3:SMAD4 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-2187392] p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-2186642] p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Rattus norvegicus [Reaction:R-RNO-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus [BlackBoxEvent:R-RNO-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling - Rattus norvegicus [Reaction:R-RNO-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Rattus norvegicus [Reaction:R-RNO-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus [Reaction:R-RNO-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Rattus norvegicus [Reaction:R-RNO-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Rattus norvegicus [Reaction:R-RNO-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus [Reaction:R-RNO-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 - Rattus norvegicus [Reaction:R-RNO-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 - Rattus norvegicus [Reaction:R-RNO-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 - Rattus norvegicus [Reaction:R-RNO-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118180
displayName	p-2S-SMAD2,3:SMAD4 [nucleoplasm]
hasMember	[Complex:R-RNO-8878153] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-206827] p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9736929] p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-2S-SMAD2,3:SMAD4 Phospho-R-SMAD:CO-SMAD complex
producedByEvent	[BlackBoxEvent:R-RNO-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Rattus norvegicus
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-173511

Referrals

(input)	[Reaction:R-RNO-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Reaction:R-RNO-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer [BlackBoxEvent:R-RNO-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling [Reaction:R-RNO-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 [Reaction:R-RNO-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-RNO-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Reaction:R-RNO-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 [Reaction:R-RNO-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 [Reaction:R-RNO-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Reaction:R-RNO-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Reaction:R-RNO-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling [Reaction:R-RNO-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
(hasComponent)	[Complex:R-RNO-1535906] SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] [Complex:R-RNO-2186642] p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] [Complex:R-RNO-2187392] p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] [Complex:R-RNO-2187322] p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] [Complex:R-RNO-2186606] p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] [Complex:R-RNO-2187302] p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] [Complex:R-RNO-9617984] FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] [Complex:R-RNO-9618006] FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] [Complex:R-RNO-2106580] WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Complex:R-RNO-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] [Complex:R-RNO-870446] p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] [Complex:R-RNO-2127250] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm]
(output)	[BlackBoxEvent:R-RNO-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus
(inferredTo)	[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]

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