Reactome | p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]

Schema > Complex > Entries

p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-NUL-2186742] p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL - Homo sapiens [Reaction:R-NUL-2186736] Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation - Homo sapiens
created	[InstanceEdit:177100] Jassal, B, 2006-03-22 11:41:32
dbId	177110
displayName	p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
hasComponent	[DefinedSet:R-HSA-349716] NCOR1, NCOR2 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [DefinedSet:R-HSA-2186620] SKI/SKIL [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Mus musculus [Complex:R-RNO-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Canis familiaris [Complex:R-BTA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Bos taurus [Complex:R-SSC-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Sus scrofa [Complex:R-GGA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Gallus gallus [Complex:R-DME-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - Drosophila melanogaster
maxDepth	4
modified	[InstanceEdit:9736955] Orlic-Milacic, Marija, 2021-07-15
name	p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR Phospho-R-SMAD:CO-SMAD:SKI complex
producedByEvent	[Reaction:R-HSA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-177110
updateTrackers	[UpdateTracker:9872235] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v41:[add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9888709] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v47:[updateContainedComponent] [UpdateTracker:9897922] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v63:[add_removeHasComponent] [UpdateTracker:9902516] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v78:[modifyName, updateContainedComponent] [UpdateTracker:9870904] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v38:[addName] [UpdateTracker:9875561] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v44:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9872235] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v41:[add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9888709] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v47:[updateContainedComponent] [UpdateTracker:9897922] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v63:[add_removeHasComponent] [UpdateTracker:9902516] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v78:[modifyName, updateContainedComponent] [UpdateTracker:9870904] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v38:[addName] [UpdateTracker:9875561] Update Tracker - [Complex:177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] - v44:[updateContainedComponent]
(hasComponent)	[Complex:R-NUL-2186742] p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 [nucleoplasm] [Complex:R-HSA-2186744] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm]
(input)	[Reaction:R-NUL-2186736] Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation [Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
(output)	[Reaction:R-HSA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling

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