Reactome | MEN1 binds SMAD2/3:SMAD4 heterotrimer

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MEN1 binds SMAD2/3:SMAD4 heterotrimer Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2186639] Orlic-Milacic, M, 2012-04-04
dbId	2186643
displayName	MEN1 binds SMAD2/3:SMAD4 heterotrimer
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2186626] MEN1 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2186644] Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling [LiteratureReference:2186647] Impaired Transforming Growth Factor-? (TGF-?) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1) [LiteratureReference:2186646] Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	MEN1 binds SMAD2/3:SMAD4 heterotrimer
negativePrecedingEvent	[NegativePrecedingEvent:9754435] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent	[Reaction:R-DME-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Drosophila melanogaster [Reaction:R-XTR-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-SSC-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Sus scrofa [Reaction:R-BTA-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Bos taurus [Reaction:R-CFA-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Canis familiaris [Reaction:R-RNO-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus [Reaction:R-MMU-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Mus musculus
output	[Complex:R-HSA-2186642] p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2186643
summation	[Summation:2186724] MEN1 (menin), a transcription factor tumor suppressor mutate...

Referrals

(hasEvent)

[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription