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Reaction
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Entries
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
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authored
[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
catalystActivity
[CatalystActivity:2176488] protein serine/threonine kinase activity of CDK8:CCNC/ CDK9:CCNT [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2176466] Orlic-Milacic, M, 2012-04-02
dbId
2176475
displayName
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
edited
[InstanceEdit:2187413] Jassal, B, 2012-04-10
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent
[Reaction:R-HSA-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3 - Homo sapiens
[Reaction:R-HSA-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2176478] Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
negativePrecedingEvent
[NegativePrecedingEvent:9754428] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent
[Reaction:R-CEL-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Caenorhabditis elegans
[Reaction:R-DME-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Drosophila melanogaster
[Reaction:R-SSC-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Sus scrofa
[Reaction:R-BTA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Bos taurus
[Reaction:R-CFA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Canis familiaris
[Reaction:R-RNO-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Rattus norvegicus
[Reaction:R-MMU-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[DefinedSet:R-HSA-2176487] p-T,2S-SMAD2,3:SMAD4 [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2176475
summation
[Summation:2176489] CDK8 in complex with cyclin C (CDK8:CCNC) and CDK9 in comple...
Referrals
(hasEvent)
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)
[Reaction:R-HSA-2176491] NEDD4L binds phosphorylated linker region of SMAD2/3
[Reaction:R-HSA-2179274] SMURF2 binds SMAD3 phosphorylated in the linker region
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