Reactome | SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling

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SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling Show undefined attributes

authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35
dbId	173481
displayName	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
edited	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35 [InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent	[Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL - Homo sapiens
input	[DefinedSet:R-HSA-349716] NCOR1, NCOR2 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [DefinedSet:R-HSA-2186620] SKI/SKIL [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:173498] Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling [LiteratureReference:2186623] Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein [LiteratureReference:2186618] The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling [LiteratureReference:2186629] SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling [LiteratureReference:2186628] TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
negativePrecedingEvent	[NegativePrecedingEvent:9754420] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
orthologousEvent	[Reaction:R-DME-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Drosophila melanogaster [Reaction:R-GGA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Gallus gallus [Reaction:R-SSC-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Sus scrofa [Reaction:R-BTA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Bos taurus [Reaction:R-CFA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Canis familiaris [Reaction:R-RNO-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Rattus norvegicus [Reaction:R-MMU-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Mus musculus
output	[Complex:R-HSA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
revised	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-173481
summation	[Summation:176015] SKI and SKIL (SNO) are able to recruit NCOR and possibly oth...
updateTrackers	[UpdateTracker:9788678] Update Tracker - [Reaction:173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - v41:[addLiteratureReference, add_removeInput, modifyText] [UpdateTracker:9789511] Update Tracker - [Reaction:173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788678] Update Tracker - [Reaction:173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - v41:[addLiteratureReference, add_removeInput, modifyText] [UpdateTracker:9789511] Update Tracker - [Reaction:173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - v38:[modifyText]
(hasEvent)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[Reaction:R-HSA-2186741] SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

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