Reactome | TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm]

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TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823728] May, Bruce, 2023-01-08
dbId	9823744
displayName	TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-211275] FOXA2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-400553] GATA4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452902] GATA6 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9758510] MIXL1 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9823747] SOX17 gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-452976] TBXT [nucleoplasm] [Complex:R-HSA-9666624] TCF7L2:CTNNB1 [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
maxDepth	4
modified	[InstanceEdit:9830221] May, Bruce, 2023-02-28
name	TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:9823735] Positive gene expression regulation by 'TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9823744
updateTrackers	[UpdateTracker:9906078] Update Tracker - [Complex:9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] - v86:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9906078] Update Tracker - [Complex:9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] - v86:[updateContainedComponent]
(output)	[Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene
(regulator)	[PositiveGeneExpressionRegulation:9823735] Positive gene expression regulation by 'TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm]'

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