Reactome | EOMES, SMAD2,3, MIXL1 bind the GSC gene

Schema > Reaction > Entries

EOMES, SMAD2,3, MIXL1 bind the GSC gene Show undefined attributes

authored	[InstanceEdit:9823884] May, Bruce, 2023-01-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823972] May, Bruce, 2023-01-13
dbId	9823966
displayName	EOMES, SMAD2,3, MIXL1 bind the GSC gene
edited	[InstanceEdit:9823884] May, Bruce, 2023-01-11
eventOf	[Pathway:R-HSA-9823730] Formation of definitive endoderm - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9823992] Expression of GSC in definitive endoderm - Homo sapiens
inferredFrom	[Reaction:R-MMU-9823983] Mixl1 binds the Gsc gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2888980] GSC gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9758510] MIXL1 [nucleoplasm] [DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:9824500] DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells
maxDepth	1
modified	[InstanceEdit:9830227] May, Bruce, 2023-02-28
name	EOMES, SMAD2,3, MIXL1 bind the GSC gene
output	[Complex:R-HSA-9823985] EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9758501] Expression of MIXL1 in the primitive streak - Homo sapiens [BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-452353] Expression of EOMES in the primitive streak - Homo sapiens
releaseDate	2023-03-29
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9830224] Salehin, Nazmus, 2023-02-28 [InstanceEdit:9830223] Tam, Patrick P L, 2023-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9823966
summation	[Summation:9825036] NODAL signaling causes the phosphorylation of SMAD2 and SMAD...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9823992] Expression of GSC in definitive endoderm
(hasEvent)	[Pathway:R-HSA-9823730] Formation of definitive endoderm
(inferredTo)	[Reaction:R-MMU-9823983] Mixl1 binds the Gsc gene