Reactome | Nuclear Pore Complex (NPC) [nuclear envelope]

Schema > Complex > Entries

Nuclear Pore Complex (NPC) [nuclear envelope] Show undefined attributes

catalystActivities	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:450099] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:5251944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:9954155] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]
compartment	[Compartment:13231] nuclear envelope
componentOf	[Complex:R-HSA-180720] nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] - Homo sapiens [Complex:R-HSA-165531] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] - Homo sapiens [Complex:R-HSA-113815] NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC - Homo sapiens [Reaction:R-HSA-2990882] CDK1 phosphorylates NUP98 - Homo sapiens [Reaction:R-HSA-75096] Docking of the TAP:EJC Complex with the NPC - Homo sapiens [Reaction:R-HSA-9708889] SARS-CoV-2 6 binds NUP98:RAE1 within NPC - Homo sapiens [Reaction:R-HSA-180710] Rev:importin beta:B23 recruited to the nuclear pore - Homo sapiens [Reaction:R-HSA-180622] Vpr binds nucleoporins - Homo sapiens [Reaction:R-HSA-9614367] HCMV Nuclear Pore Docking - Homo sapiens
created	[InstanceEdit:157706] Gillespie, ME, 2005-01-05 21:25:13
dbId	157689
displayName	Nuclear Pore Complex (NPC) [nuclear envelope]
hasComponent	8 × [EntityWithAccessionedSequence:R-HSA-157738] AAAS [nuclear envelope] 32 × [EntityWithAccessionedSequence:R-HSA-6805183] NDC1 [nuclear envelope] 32 × [Complex:R-HSA-377883] Nup107-160 complex [cytosol] 8 × [EntityWithAccessionedSequence:R-HSA-157695] NUP153 [nucleoplasm] 16 × [EntityWithAccessionedSequence:R-HSA-157752] NUP188 [nuclear envelope] 16 × [EntityWithAccessionedSequence:R-HSA-157722] NUP210 [nuclear envelope] 8 × [EntityWithAccessionedSequence:R-HSA-157691] NUP214 [cytosol] 32 × [EntityWithAccessionedSequence:R-HSA-157740] NUP50 [nucleoplasm] 32 × [Complex:R-HSA-157712] Nup62 Complex [nuclear envelope] 32 × [EntityWithAccessionedSequence:R-HSA-157753] NUP88 [cytosol] 32 × [Complex:R-HSA-9634183] Nup93 complex [nuclear envelope] 8 × [CandidateSet:R-HSA-2990879] NUP98 [nuclear envelope] 16 × [EntityWithAccessionedSequence:R-HSA-157697] NUPL2 [cytosol] 16 × [DefinedSet:R-HSA-6805169] POM121 [nuclear envelope] 48 × [EntityWithAccessionedSequence:R-HSA-157718] RAE1 [nuclear envelope] 8 × [EntityWithAccessionedSequence:R-HSA-157703] RANBP2 [cytosol] 16 × [EntityWithAccessionedSequence:R-HSA-157750] SEH1L-2 [nuclear envelope] 16 × [EntityWithAccessionedSequence:R-HSA-157692] TPR [nucleoplasm]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
inferredTo	[Complex:R-MMU-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Mus musculus [Complex:R-RNO-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Rattus norvegicus [Complex:R-CFA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Canis familiaris [Complex:R-BTA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Bos taurus [Complex:R-SSC-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Sus scrofa [Complex:R-DRE-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Danio rerio [Complex:R-XTR-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Xenopus tropicalis [Complex:R-GGA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Gallus gallus [Complex:R-DME-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Drosophila melanogaster [Complex:R-CEL-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Caenorhabditis elegans [Complex:R-SPO-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Schizosaccharomyces pombe
isRequired	[Requirement:R-HSA-191812] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159062] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159055] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159063] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159293] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159295] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159294] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159066] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159051] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159060] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159067] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159053] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159057] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-188869] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-192711] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-191896] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
literatureReference	[LiteratureReference:157698] Peering through the pore: nuclear pore complex structure, assembly, and function [LiteratureReference:157701] Proteomic analysis of the mammalian nuclear pore complex [LiteratureReference:157696] Mapping the dynamic organization of the nuclear pore complex inside single living cells [LiteratureReference:6805176] Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines [LiteratureReference:9618425] Architecture of the symmetric core of the nuclear pore [LiteratureReference:9618439] Molecular architecture of the inner ring scaffold of the human nuclear pore complex [LiteratureReference:9618440] The nuclear pore complex--structure and function at a glance
maxDepth	4
modified	[InstanceEdit:9634236] Orlic-Milacic, Marija, 2019-01-07
name	Nuclear Pore Complex (NPC)
positivelyRegulates	[Requirement:R-HSA-191812] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159062] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159055] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159063] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159293] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159295] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159294] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159066] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159051] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159060] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159067] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159053] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159057] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-188869] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-192711] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-191896] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
producedByEvent	[Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm - Homo sapiens [Reaction:R-HSA-180732] Translocation of Rev:importin-beta:B23 to the nucleus - Homo sapiens [Reaction:R-HSA-9614369] Transport of HCMV DNA Into the Nucleus - Homo sapiens [Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-157689
updateTrackers	[UpdateTracker:9899744] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v67:[addLiteratureReference, add_removeHasComponent] [UpdateTracker:9867085] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v25:[updateContainedComponent] [UpdateTracker:9893285] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v55:[addLiteratureReference, add_removeHasComponent] [UpdateTracker:9879137] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v44:[add_removeHasComponent] [UpdateTracker:9900068] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v68:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9867897] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v27:[updateContainedComponent]

Referrals

(hasComponent)	[Complex:R-HSA-165531] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope] [Complex:R-HSA-180720] nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope] [Complex:R-HSA-180610] PIC anchored to the NPC [nuclear envelope] [Complex:R-HSA-113815] NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] [Complex:R-HSA-159259] NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] [Complex:R-HSA-9614366] HCMV Capsid:Nuclear Pore Complex [nuclear envelope] [Complex:R-HSA-9708891] 6:NPC [nuclear envelope]
(input)	[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC [Reaction:R-HSA-180710] Rev:importin beta:B23 recruited to the nuclear pore [Reaction:R-HSA-180622] Vpr binds nucleoporins [Reaction:R-HSA-2990882] CDK1 phosphorylates NUP98 [Reaction:R-HSA-75096] Docking of the TAP:EJC Complex with the NPC [Reaction:R-HSA-9614367] HCMV Nuclear Pore Docking [Reaction:R-HSA-9708889] SARS-CoV-2 6 binds NUP98:RAE1 within NPC
(output)	[Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm [Reaction:R-HSA-180732] Translocation of Rev:importin-beta:B23 to the nucleus [Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC [Reaction:R-HSA-9614369] Transport of HCMV DNA Into the Nucleus
(physicalEntity)	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:450099] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:5251944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] [CatalystActivity:9954155] narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]
(regulator)	[Requirement:R-HSA-191812] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159062] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159055] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159063] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159293] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159295] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159294] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159066] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159051] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159060] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159067] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159053] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-159057] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-188869] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-192711] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]' [Requirement:R-HSA-191896] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
(requiredInputComponent)	[BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus [BlackBoxEvent:R-HSA-3371527] HSF1 trimer translocates to the nucleus [Reaction:R-HSA-913529] Translocation of p-STAT1:p-STAT1 dimer to nucleus [BlackBoxEvent:R-HSA-3134914] Beta-catenin migrates to the nucleus [Reaction:R-HSA-9604480] NFkB complex translocates from the cytosol to the nucleus [Reaction:R-HSA-2032396] Dimerized phospho-IRF3 migrates to the nucleus [Reaction:R-HSA-909721] Translocation of ISGF3 complex to nucleus [Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm [Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus [Reaction:R-HSA-9768142] Dimerized phospho-IRF3, IRF7 is transported to the nucleus [Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus [Reaction:R-HSA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus
(normalEntity)	[EntityFunctionalStatus:5661409] loss_of_function of Defective NPC [nuclear envelope]
(updatedInstance)	[UpdateTracker:9899744] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v67:[addLiteratureReference, add_removeHasComponent] [UpdateTracker:9867085] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v25:[updateContainedComponent] [UpdateTracker:9893285] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v55:[addLiteratureReference, add_removeHasComponent] [UpdateTracker:9879137] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v44:[add_removeHasComponent] [UpdateTracker:9900068] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v68:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9867897] Update Tracker - [Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] - v27:[updateContainedComponent]

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