Reactome | Dimerized phospho-IRF3 migrates to the nucleus

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Dimerized phospho-IRF3 migrates to the nucleus Show undefined attributes

authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:2032395] Shamovsky, V, 2012-01-06
dbId	2032396
displayName	Dimerized phospho-IRF3 migrates to the nucleus
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN - Homo sapiens [Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN - Homo sapiens
followingEvent	[Reaction:R-HSA-3134883] Beta-catenin enhances association of IRF3 with CBP/p300 - Homo sapiens
input	[Complex:R-HSA-166272] p-T,4S-IRF3:p-T,4S-IRF3 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Dimerized phospho-IRF3 migrates to the nucleus
orthologousEvent	[Reaction:R-MMU-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Mus musculus [Reaction:R-SSC-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Sus scrofa [Reaction:R-BTA-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Bos taurus [Reaction:R-CFA-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Canis familiaris [Reaction:R-RNO-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Rattus norvegicus
output	[Complex:R-HSA-177675] p-T,4S-IRF3:p-T,4S-IRF3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2395992] p-T,4S-IRF3 is dimerized - Homo sapiens
releaseDate	2012-03-13
requiredInputComponent	[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19 [InstanceEdit:2453959] Jin, Lei, 2012-08-18 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2032396
summation	[Summation:178674] IRF3-P:IRF3-P' is translocated from cytosol to nucleoplasm.

Referrals

(precedingEvent)	[Reaction:R-HSA-3134883] Beta-catenin enhances association of IRF3 with CBP/p300
(hasEvent)	[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN [Pathway:R-HSA-1606341] IRF3 mediated activation of type 1 IFN

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