Reactome | Docking of the TAP:EJC Complex with the NPC

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Docking of the TAP:EJC Complex with the NPC Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:75101] Hammarskjold, ML, 2003-08-22 13:02:53
dbId	75096
displayName	Docking of the TAP:EJC Complex with the NPC
eventOf	[Pathway:R-HSA-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-75097] Transport of the export-competent mRNP complex through the NPC - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:4519] mRNA export from nucleus
input	[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Complex:R-HSA-159100] NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8850715] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus [LiteratureReference:8850681] The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences [LiteratureReference:8850709] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human [LiteratureReference:8850720] The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates [LiteratureReference:8850684] Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins [LiteratureReference:8850694] Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes [LiteratureReference:8850702] Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling [LiteratureReference:8850731] RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Docking of the TAP:EJC Complex with the NPC
output	[CandidateSet:R-HSA-8852182] ALYREF, FYTTD1, LUZP4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72062] CDC40 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849147] CHTOP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72073] hSLU7 [nucleoplasm] [Complex:R-HSA-113815] NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849146] SARNP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72031] SRSF1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72058] SRSF11 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72033] SRSF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72035] SRSF3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72024] SRSF4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72028] SRSF5 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72026] SRSF6 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72029] SRSF7 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72037] SRSF9 [nucleoplasm] [Complex:R-HSA-8849128] THO complex [nucleoplasm] [DefinedSet:R-HSA-8865886] U2AF1,U2AF1L4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-71987] U2AF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8850659] ZC3H11A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - Homo sapiens
regulatedBy	[Requirement:R-HSA-159293] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75096
summation	[Summation:178695] At the beginning of this reaction, 1 molecule of 'TAP:3'-pol...
updateTrackers	[UpdateTracker:9783610] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v56:[addInput, addLiteratureReference, add_removeOutput] [UpdateTracker:9784617] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v53:[removeOutput] [UpdateTracker:9783012] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v57:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783610] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v56:[addInput, addLiteratureReference, add_removeOutput] [UpdateTracker:9784617] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v53:[removeOutput] [UpdateTracker:9783012] Update Tracker - [Reaction:75096] Docking of the TAP:EJC Complex with the NPC - v57:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript
(precedingEvent)	[BlackBoxEvent:R-HSA-75097] Transport of the export-competent mRNP complex through the NPC

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