Reactome | HSF1 trimer translocates to the nucleus

Schema > BlackBoxEvent > Entries

HSF1 trimer translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:4793943] Shamovsky, V, 2013-10-28
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371527
displayName	HSF1 trimer translocates to the nucleus
edited	[InstanceEdit:5324627] Shamovsky, V, 2014-02-17
eventOf	[Pathway:R-HSA-3371511] HSF1 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-4793819] HSF1 trimer binds HSE on the target gene - Homo sapiens
input	[Complex:R-HSA-4793915] HSF1 trimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4793691] Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1 [LiteratureReference:4793714] Constitutive nuclear import and stress-regulated nucleocytoplasmic shuttling of mammalian heat-shock factor 1
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HSF1 trimer translocates to the nucleus
orthologousEvent	[BlackBoxEvent:R-SCE-3371527] HSF1 trimer translocates to the nucleus - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-3371527] HSF1 trimer translocates to the nucleus - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-3371527] HSF1 trimer translocates to the nucleus - Dictyostelium discoideum [BlackBoxEvent:R-CEL-3371527] HSF1 trimer translocates to the nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-3371527] HSF1 trimer translocates to the nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-3371527] HSF1 trimer translocates to the nucleus - Gallus gallus [BlackBoxEvent:R-DRE-3371527] HSF1 trimer translocates to the nucleus - Danio rerio [BlackBoxEvent:R-SSC-3371527] HSF1 trimer translocates to the nucleus - Sus scrofa [BlackBoxEvent:R-BTA-3371527] HSF1 trimer translocates to the nucleus - Bos taurus [BlackBoxEvent:R-CFA-3371527] HSF1 trimer translocates to the nucleus - Canis familiaris [BlackBoxEvent:R-RNO-3371527] HSF1 trimer translocates to the nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-3371527] HSF1 trimer translocates to the nucleus - Mus musculus
output	[Complex:R-HSA-4793790] HSF1 trimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3371591] Trimerization of cytosolic HSF1 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-4793638] Negative regulation by 'YWHAE dimer [cytosol]'
releaseDate	2014-03-12
requiredInputComponent	[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5324628] Pani, Bibhusita, 2014-02-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3371527
summation	[Summation:3371572] There is no consensus on whether inactive HSF1 monomers loca...

Referrals

(hasEvent)	[Pathway:R-HSA-3371511] HSF1 activation
(precedingEvent)	[Reaction:R-HSA-4793819] HSF1 trimer binds HSE on the target gene