Reactome | Translocation of nuclear RNA transport complex to cytoplasm

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Translocation of nuclear RNA transport complex to cytoplasm Show undefined attributes

authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:165042] Matthews, L, 2005-07-26 23:04:06
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	165047
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Translocation of nuclear RNA transport complex to cytoplasm
edited	[InstanceEdit:182779] Matthews, L, 2006-07-13 06:31:19
eventOf	[Pathway:R-HSA-165054] Rev-mediated nuclear export of HIV RNA - Homo sapiens
followingEvent	[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP - Homo sapiens [Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex - Homo sapiens
input	[Complex:R-HSA-165531] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:165038] The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm [LiteratureReference:165060] Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of nuclear RNA transport complex to cytoplasm
output	[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Complex:R-HSA-165552] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol]
precedingEvent	[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192365] Kumar, A, 2007-01-31 22:47:49
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-165047
summation	[Summation:165029] Crm1 is a nucleocytoplasmic transport factor that is believe...

Referrals

(precedingEvent)	[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP [Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
(hasEvent)	[Pathway:R-HSA-165054] Rev-mediated nuclear export of HIV RNA

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