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Entries
Phosphorylated MKK3/MKK6 migrates to nucleus
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authored
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId
450296
displayName
Phosphorylated MKK3/MKK6 migrates to nucleus
edited
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf
[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent
[Reaction:R-HSA-8877691] MAP2K6 phosphorylates PIP4K2B - Homo sapiens
[Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Homo sapiens
[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens
input
[DefinedSet:R-HSA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:442922] Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
modified
[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name
Phosphorylated MKK3/MKK6 migrates to nucleus
orthologousEvent
[Reaction:R-GGA-442938] activated MAPK3/MAPK6 migrates to nucleus - Gallus gallus
[Reaction:R-DDI-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Dictyostelium discoideum
[Reaction:R-CEL-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Caenorhabditis elegans
[Reaction:R-DME-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Drosophila melanogaster
[Reaction:R-GGA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Gallus gallus
[Reaction:R-XTR-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Xenopus tropicalis
[Reaction:R-DRE-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Danio rerio
[Reaction:R-SSC-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Sus scrofa
[Reaction:R-BTA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Bos taurus
[Reaction:R-CFA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Canis familiaris
[Reaction:R-RNO-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Rattus norvegicus
[Reaction:R-MMU-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Mus musculus
output
[DefinedSet:R-HSA-450343] p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens
[Reaction:R-HSA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Homo sapiens
releaseDate
2010-12-14
requiredInputComponent
[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Homo sapiens
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-450296
summation
[Summation:444070] The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were pres...
Referrals
(precedingEvent)
[Reaction:R-HSA-8877691] MAP2K6 phosphorylates PIP4K2B
[Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5
[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
(hasEvent)
[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation
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