Reactome | Phosphorylated MKK3/MKK6 migrates to nucleus

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Phosphorylated MKK3/MKK6 migrates to nucleus Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450296
displayName	Phosphorylated MKK3/MKK6 migrates to nucleus
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-8877691] MAP2K6 phosphorylates PIP4K2B - Homo sapiens [Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Homo sapiens [Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens
input	[DefinedSet:R-HSA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:442922] Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2 [LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylated MKK3/MKK6 migrates to nucleus
orthologousEvent	[Reaction:R-GGA-442938] activated MAPK3/MAPK6 migrates to nucleus - Gallus gallus [Reaction:R-SCE-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Saccharomyces cerevisiae [Reaction:R-SPO-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Schizosaccharomyces pombe [Reaction:R-DDI-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Dictyostelium discoideum [Reaction:R-CEL-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Caenorhabditis elegans [Reaction:R-DME-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Drosophila melanogaster [Reaction:R-GGA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Gallus gallus [Reaction:R-XTR-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Xenopus tropicalis [Reaction:R-DRE-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Danio rerio [Reaction:R-SSC-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Sus scrofa [Reaction:R-BTA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Bos taurus [Reaction:R-CFA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Canis familiaris [Reaction:R-RNO-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Rattus norvegicus [Reaction:R-MMU-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Mus musculus
output	[DefinedSet:R-HSA-450343] p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens [Reaction:R-HSA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Homo sapiens
releaseDate	2010-12-14
requiredInputComponent	[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450296
summation	[Summation:444070] The p38 activators MKK3 (MAP2K3) and MKK6 (MAP2K6) were pres...
updateTrackers	[UpdateTracker:9780108] Update Tracker - [Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus - v64:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780108] Update Tracker - [Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus - v64:[modifyText]
(precedingEvent)	[Reaction:R-HSA-8877691] MAP2K6 phosphorylates PIP4K2B [Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 [Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation

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