Reactome | Mycobacterium tuberculosis

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Mycobacterium tuberculosis Show undefined attributes

abbreviation	MTU
created	[InstanceEdit:176807] D'Eustachio, P, 2006-03-10 16:49:54
crossReference	[DatabaseIdentifier:176777] NCBI_taxonomy:1773
dbId	176806
displayName	Mycobacterium tuberculosis
modified	[InstanceEdit:9014479] Weiser, JD
name	Mycobacterium tuberculosis
schemaClass	Species
superTaxon	[Taxon:176769] Mycobacterium tuberculosis complex
taxId	1773

Referrals

(superTaxon)

[Species:5545372] Mycobacterium tuberculosis H37Rv

(relatedSpecies)

[Pathway:R-HSA-5663205] Infectious disease
[Pathway:R-HSA-9635486] Infection with Mycobacterium tuberculosis
[Pathway:R-HSA-9637628] Modulation by Mtb of host immune system
[Reaction:R-HSA-9637641] Rv2779c binds TLR2
[Complex:R-HSA-9637603] Rv2779c:TLR2 [plasma membrane]
[Reaction:R-HSA-9637605] PstS1 binds MRC1
[Complex:R-HSA-9637625] PstS1:MRC1 [plasma membrane]
[Reaction:R-HSA-9637638] EsxA binds TLR2
[Complex:R-HSA-9637604] EsxA:TLR2 [plasma membrane]
[Reaction:R-HSA-9637635] EsxA binds B2M
[Complex:R-HSA-9637621] EsxA:B2M [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9637651] EsxA translocates from Mtb cytosol to the host's ER
[Pathway:R-HSA-9639775] Antimicrobial action and antimicrobial resistance in Mtb
[Polymerisation:R-HSA-9697084] Defective RpoB in Mtb RNAP transcribes RNA polyanion
[Polymerisation:R-HSA-9697085] RNAP transcribes Mtb RNA polyanion
[Reaction:R-HSA-9697086] Rifampicin binds Mtb RNAP
[Pathway:R-HSA-9637679] Escape of Mtb from the phagocyte
[Pathway:R-HSA-9637698] Phagocyte cell death caused by cytosolic Mtb
[Reaction:R-HSA-9637699] CpnT hydrolyses NAD+
[Pathway:R-HSA-9637690] Response of Mtb to phagocytosis
[Pathway:R-HSA-9635644] Inhibition of membrane repair
[Pathway:R-HSA-9636569] Suppression of autophagy
[Reaction:R-HSA-9636564] SapM binds RAB7A
[Complex:R-HSA-9636582] SapM:RAB7 [phagocytic vesicle membrane]
[Reaction:R-HSA-9636560] Eis acetylates DUSP16
[Pathway:R-HSA-9635465] Suppression of apoptosis
[Reaction:R-HSA-9636296] Mce3E binds MAPK1
[Complex:R-HSA-9636301] Mce3E:MAPK1 [endoplasmic reticulum lumen]
[Reaction:R-HSA-9636297] PtpA binds TRIM27
[Complex:R-HSA-9636303] PtpA:TRIM27 [cytosol]
[Reaction:R-HSA-9635609] Rv3655c binds RNF213
[Complex:R-HSA-9635608] Rv3655c:RFN213 [cytosol]
[Reaction:R-HSA-9635461] PtpA dephosphorylates GSK3A
[Reaction:R-HSA-9635446] Rv3654c binds SFPQ
[Complex:R-HSA-9635500] Rv3654c:SFPQ [cytosol]
[Reaction:R-HSA-9636304] Mce3E binds MAPK3
[Complex:R-HSA-9636300] Mce3E:MAPK3 [endoplasmic reticulum lumen]
[Reaction:R-HSA-9635424] Rv3364c binds cathepsin G
[Complex:R-HSA-9635457] Rv3364c:CTSG [cytosol]
[Pathway:R-HSA-9636667] Manipulation of host energy metabolism
[Reaction:R-HSA-9636669] EsxA binds ENO1
[Complex:R-HSA-9636657] EsxA:ENO1 [cytosol]
[Reaction:R-HSA-9636658] EsxA binds PGK1
[Complex:R-HSA-9636663] EsxA:PGK1 [cytosol]
[Pathway:R-HSA-9637687] Suppression of phagosomal maturation
[Pathway:R-HSA-9636383] Prevention of phagosomal-lysosomal fusion
[Reaction:R-HSA-9636684] NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP
[Reaction:R-HSA-9636396] LpdC binds to CORO1A
[Complex:R-HSA-9636422] LpdC:CORO1A [cytosol]
[Reaction:R-HSA-9636457] SapM dephosphorylates PI3P
[BlackBoxEvent:R-HSA-9636404] LAM translocates from the cell wall to the plasma membrane
[Reaction:R-HSA-9697070] LprG dissociates from LAM,LM
[BlackBoxEvent:R-HSA-9697077] Rv1410c transports LprG:LM,LAM from cytosol to the cell wall
[Reaction:R-HSA-9697064] LprG binds to LAM,LM
[BlackBoxEvent:R-HSA-9636375] SecA2 transports SapM from cytoplasm to cytosol
[Reaction:R-HSA-9636439] PtpA:Ub dephosphorylates p-Y133-VPS33B
[Reaction:R-HSA-9636461] PtpA binds Ubiquitin
[Complex:R-HSA-9636421] PtpA:Ub [cytosol]
[Reaction:R-HSA-9635667] EsxG:EsxH binds HGS
[BlackBoxEvent:R-HSA-9635666] EsxG:EsxH translocates from MTb cytosol to host phagosomal lumen
[Reaction:R-HSA-9697057] EsxG binds esxH
[Complex:R-HSA-9635651] HGS:esxG:esxH [phagocytic vesicle lumen]
[Pathway:R-HSA-9636249] Inhibition of nitric oxide production
[BlackBoxEvent:R-HSA-9636261] NOS2 gene produces NOS2 protein
[Reaction:R-HSA-9636240] PPE2 binds NOS2 gene
[Complex:R-HSA-9636241] PPE2:NOS2 gene [nucleoplasm]
[Reaction:R-HSA-9636242] PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus
[BlackBoxEvent:R-HSA-9636247] PPE2:KPNA1:KPNB1 translocates to the nucleus
[Reaction:R-HSA-9636251] PPE2 binds KPNA1:KPNB1
[Complex:R-HSA-9636269] PPE2:KPNA1:KPNB1 [cytosol]
[Complex:R-HSA-9636243] PPE2:KPNA1:KPNB1 [nucleoplasm]
[Pathway:R-HSA-9636467] Blockage of phagosome acidification
[Reaction:R-HSA-9636397] PtpA binds ATP6V1H
[Complex:R-HSA-9636500] PtpA:ATP6V1H [cytosol]
[Pathway:R-HSA-1222499] Latent infection - Other responses of Mtb to phagocytosis
[Pathway:R-HSA-1222541] Cell redox homeostasis
[Reaction:R-HSA-1222412] LpdC dimer reactivates DlaT
[Reaction:R-HSA-1500781] Fgd1 reactivates F420
[Reaction:R-HSA-1222485] TrxB reactivates TrxA
[Reaction:R-HSA-1222644] TrxA/B1 reactivates Tpx
[Reaction:R-HSA-1222417] TrxA reactivates AhpC
[Reaction:R-HSA-1222690] DlaT reactivates AhpD
[Reaction:R-HSA-1222655] AhpD reactivates AhpC
[Pathway:R-HSA-1222538] Tolerance by Mtb to nitric oxide produced by macrophages
[Reaction:R-HSA-1500761] Nitrogen dioxide is reduced to NO by F420
[Reaction:R-HSA-1222431] Peroxynitrite is reduced to nitrite by AhpC
[Reaction:R-HSA-1222712] Nitrosoglutathione gets cleaved to Cys(NO)-Gly
[Reaction:R-HSA-1222363] MsrA/B reduces peptide-methionine S/R-sulfoxides
[Reaction:R-HSA-1500817] Glutathione is taken up by the bacterium
[Reaction:R-HSA-1222583] MscR reduces nitrosomycothiol to ammonia
[Reaction:R-HSA-1500804] Peroxynitrite is reduced by AhpE
[Reaction:R-HSA-1222755] Peroxynitrite is reduced to nitrite by Tpx
[Reaction:R-HSA-1222723] Nitric oxide is oxidized to nitrate
[Reaction:R-HSA-1222594] Mycothiol scavenges nitrosyl
[Pathway:R-HSA-1222449] Mtb iron assimilation by chelation
[Reaction:R-HSA-1222399] Iron is reduced and separates from mycobactin
[Reaction:R-HSA-1562603] BfrB stores iron
[Reaction:R-HSA-1562604] BfrA stores iron
[Reaction:R-HSA-8951552] LTF:2xCO3(2-) dissociates from Carbocymycobactin:Fe3+
[Reaction:R-HSA-1222597] Loaded mycobactin gets imported
[Reaction:R-HSA-1222325] Carboxymycobactin and mycobactin exchange their iron load
[Complex:R-HSA-3244625] cGAS:dsDNA [cytosol]
[Reaction:R-HSA-3244647] cGAS binds cytosolic DNA
[Reaction:R-HSA-3244614] cGAS produces cyclic GMP-AMP
[BlackBoxEvent:R-HSA-6789077] Hydrogen peroxide enters the bacterium
[Reaction:R-HSA-6789160] Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+
[BlackBoxEvent:R-HSA-1222662] Nitric oxide enters the bacterium
[BlackBoxEvent:R-HSA-1222342] Hydroperoxyl enters the bacterium
[BlackBoxEvent:R-HSA-1470073] Peroxynitrite enters the bacterium
[Reaction:R-HSA-1222411] Peroxynitrite oxidizes Peptide-Methionine residues
[Reaction:R-HSA-5621606] CD209 binds ManLAM
[BlackBoxEvent:R-HSA-5621573] CD209 activate GTPase RAS
[Pathway:R-HSA-5621575] CD209 (DC-SIGN) signaling
[Pathway:R-HSA-5621481] C-type lectin receptors (CLRs)
[Reaction:R-HSA-1222469] SodC reduces superoxide to H2O2
[Reaction:R-HSA-1222462] SodB reduces superoxide to H2O2
[Reaction:R-HSA-1222704] KatG reduces H2O2
[Reaction:R-HSA-1222341] H2O2 gets scavenged by unsaturated lipid
[Reaction:R-HSA-1222346] AhpC reduces H2O2
[Reaction:R-HSA-1222523] SodB gets secreted
[Reaction:R-HSA-1222526] AhpC reduces peroxidated lipids
[Pathway:R-HSA-1222387] Tolerance of reactive oxygen produced by macrophages
[BlackBoxEvent:R-HSA-1222738] Carboxymycobactin gets secreted
[Reaction:R-HSA-1222722] Mycobactin is exported
[Reaction:R-HSA-1222641] Carboxymycobactin binds LTF:2xFe3+:2xCO3(2-)
[Reaction:R-HSA-8951549] Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-)

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