Reactome | Defective rpoB in Mtb RNAP transcribes RNA polyanion

Schema > Polymerisation > Entries

Defective rpoB in Mtb RNAP transcribes RNA polyanion Show undefined attributes

authored	[InstanceEdit:9638888] Stephan, Ralf, 2019-03-06
catalystActivity	[CatalystActivity:9638869] DNA-directed 5'-3' RNA polymerase activity of mutant RNAP [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9697083] Jassal, Bijay, 2020-08-05
dbId	9697084
disease	[Disease:1660556] tuberculosis
displayName	Defective rpoB in Mtb RNAP transcribes RNA polyanion
edited	[InstanceEdit:9697083] Jassal, Bijay, 2020-08-05
eventOf	[Pathway:R-HSA-9639775] Antimicrobial action and antimicrobial resistance in Mtb - Homo sapiens
input	[SimpleEntity:R-ALL-9638778] RNA polyanion [cytosol] [SimpleEntity:R-ALL-9638762] RNTP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9638856] Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance [LiteratureReference:9638870] Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis [LiteratureReference:9638834] Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the ?' Subunit
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective rpoB in Mtb RNAP transcribes RNA polyanion
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Polymer:R-ALL-9638756] RNA(n+1) [cytosol]
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9664478] Deffur, Armin, Wilkinson, RJ, 2019-10-23
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-9697084
summation	[Summation:9638868] Mutations in several regions of bacterial RNA polymerase (RN...

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(hasEvent)

[Pathway:R-HSA-9639775] Antimicrobial action and antimicrobial resistance in Mtb

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