Reactome | PPE2 binds NOS2 gene

Schema > Reaction > Entries

authored	[InstanceEdit:9635702] Stephan, Ralf, 2019-02-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9636267] Koile, Daniel, 2019-02-12
crossReference	[DatabaseIdentifier:12020769] Mondo:0018076
dbId	9636240
disease	[Disease:1660556] tuberculosis
displayName	PPE2 binds NOS2 gene
edited	[InstanceEdit:9636267] Koile, Daniel, 2019-02-12
eventOf	[Pathway:R-HSA-9636249] Inhibition of nitric oxide production - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8948450] NOS2 gene [nucleoplasm] [EntityWithAccessionedSequence:R-MTU-9636258] PPE2 [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9636246] The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PPE2 binds NOS2 gene
output	[Complex:R-HSA-9636241] PPE2:NOS2 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9636242] PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus - Homo sapiens
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9664478] Deffur, Armin, Wilkinson, RJ, 2019-10-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9636240
summation	[Summation:9636252] PPE famly protein PPE2 binds to regulatory elements of the i...

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