Reactome | cGAS binds cytosolic DNA

Schema > Reaction > Entries

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
dbId	3244647
displayName	cGAS binds cytosolic DNA
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-1834941] STING mediated induction of host immune responses - Homo sapiens
followingEvent	[Reaction:R-HSA-3244614] cGAS produces cyclic GMP-AMP - Homo sapiens
input	[DefinedSet:R-NUL-8982071] cGAS ligands [cytosol] [EntityWithAccessionedSequence:R-HSA-3244653] MB21D1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3244594] Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	cGAS binds cytosolic DNA
output	[Complex:R-HSA-3244625] cGAS:dsDNA [cytosol]
relatedSpecies	[Species:5689680] Human herpesvirus 1 [Species:164493] Human immunodeficiency virus 1 [Species:8875362] Listeria monocytogenes [Species:176806] Mycobacterium tuberculosis
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3244647
summation	[Summation:3249346] Cyclic GMP-AMP (cGAMP) synthase (cGAS) was identified as a c...

(hasEvent)	[Pathway:R-HSA-1834941] STING mediated induction of host immune responses
(precedingEvent)	[Reaction:R-HSA-3244614] cGAS produces cyclic GMP-AMP

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