Reactome | PPE2:KPNA1:KPNB1 translocates to the nucleus

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9635702] Stephan, Ralf, 2019-02-06
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9636267] Koile, Daniel, 2019-02-12
crossReference	[DatabaseIdentifier:12020769] Mondo:0018076
dbId	9636247
disease	[Disease:1660556] tuberculosis
displayName	PPE2:KPNA1:KPNB1 translocates to the nucleus
edited	[InstanceEdit:9636267] Koile, Daniel, 2019-02-12
eventOf	[Pathway:R-HSA-9636249] Inhibition of nitric oxide production - Homo sapiens
followingEvent	[Reaction:R-HSA-9636242] PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus - Homo sapiens
input	[Complex:R-HSA-9636269] PPE2:KPNA1:KPNB1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9636246] The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PPE2:KPNA1:KPNB1 translocates to the nucleus
output	[Complex:R-HSA-9636243] PPE2:KPNA1:KPNB1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9636251] PPE2 binds KPNA1:KPNB1 - Homo sapiens
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9664478] Deffur, Armin, Wilkinson, RJ, 2019-10-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9636247
summation	[Summation:9636244] PPE family protein PPE2 is translocated to the phagocyte's n...

(hasEvent)	[Pathway:R-HSA-9636249] Inhibition of nitric oxide production
(precedingEvent)	[Reaction:R-HSA-9636242] PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus

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