Reactome | Peroxynitrite is reduced to nitrite by Tpx

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Peroxynitrite is reduced to nitrite by Tpx Show undefined attributes

authored	[InstanceEdit:1222281] Stephan, R, 2011-01-10
catalystActivity	[CatalystActivity:1222606] peroxiredoxin activity of Tpx dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1222482] Jassal, B, 2011-02-28
crossReference	[DatabaseIdentifier:12020769] Mondo:0018076
dbId	1222755
disease	[Disease:1660556] tuberculosis
displayName	Peroxynitrite is reduced to nitrite by Tpx
edited	[InstanceEdit:1222482] Jassal, B, 2011-02-28
eventOf	[Pathway:R-HSA-1222538] Tolerance by Mtb to nitric oxide produced by macrophages - Homo sapiens
followingEvent	[Reaction:R-HSA-1222644] TrxA/B1 reactivates Tpx - Homo sapiens
input	2 × [SimpleEntity:R-ALL-1222481] Peroxynitrite [cytosol] 2 × [EntityWithAccessionedSequence:R-MTU-1222392] Tpx [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1222378] Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis [LiteratureReference:1222577] Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Peroxynitrite is reduced to nitrite by Tpx
output	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-1222379] Nitrite [cytosol] 2 × [EntityWithAccessionedSequence:R-MTU-1222496] Tpx(ox.) [cytosol]
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2213261] Warner, D, 2012-04-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1222755
summation	[Summation:1222336] Tpx, like AhpC, is a peroxiredoxin with alkylhydroperoxidase...

Referrals

(precedingEvent)	[Reaction:R-HSA-1222644] TrxA/B1 reactivates Tpx
(hasEvent)	[Pathway:R-HSA-1222538] Tolerance by Mtb to nitric oxide produced by macrophages

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