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Glycosphingolipid biosynthesis
Stable Identifier
R-HSA-9840309
Type
Pathway
Species
Homo sapiens
Compartment
Golgi lumen
,
Golgi membrane
,
endoplasmic reticulum lumen
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid biosynthesis (Homo sapiens)
General
SBML
|
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Level 2
Level 3
|
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|
PNG
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|
PPTX
|
SBGN
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The steps involved in the synthesis of glycosphingolipids (sphingolipids with one or more sugars attached) are annotated here (the topic is reviewed by Sandhoff & Sandhoff, 2018; Sandhoff et al, 2018).
Literature References
PubMed ID
Title
Journal
Year
29747811
Ganglioside Metabolism in Health and Disease
Sandhoff, R
,
Schulze, H
,
Sandhoff, K
Prog Mol Biol Transl Sci
2018
29802621
Emerging concepts of ganglioside metabolism
Sandhoff, R
,
Sandhoff, K
FEBS Lett
2018
Participants
Events
UGT8 transfers Gal from UDP-Gal to CERA
(Homo sapiens)
GAL3ST1 transfers sulfate to GalCer,LacCer
(Homo sapiens)
ST3GAL5 transfers NeuNAc to ceramides
(Homo sapiens)
UGCG transfers glucose to ceramide
(Homo sapiens)
B4GALT5/6 transfer Gal to GlcCer
(Homo sapiens)
B4GALNT1 dimer transfers GalNAc to gangliosides
(Homo sapiens)
B3GALT4 transfers Gal to gangliosides
(Homo sapiens)
ST3GAL2,3 transfer Neu5Ac to gangliosides
(Homo sapiens)
ST8SIA5 transfers Neu5Ac to gangliosides
(Homo sapiens)
ST6GALNAC5,6 transfer Neu5Ac to GM1b
(Homo sapiens)
FUT1,2 transfer fucose to gangliosides
(Homo sapiens)
A4GALT transfers galactose to LacCer
(Homo sapiens)
B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer
(Homo sapiens)
B3GNT5 transfers GlcNAc to LacCer
(Homo sapiens)
CERK phosphorylates CERA to form C1P
(Homo sapiens)
Participates
as an event of
Glycosphingolipid metabolism (Homo sapiens)
Event Information
Go Biological Process
glycosphingolipid biosynthetic process (0006688)
Orthologous Events
Glycosphingolipid biosynthesis (Bos taurus)
Glycosphingolipid biosynthesis (Caenorhabditis elegans)
Glycosphingolipid biosynthesis (Canis familiaris)
Glycosphingolipid biosynthesis (Danio rerio)
Glycosphingolipid biosynthesis (Drosophila melanogaster)
Glycosphingolipid biosynthesis (Gallus gallus)
Glycosphingolipid biosynthesis (Mus musculus)
Glycosphingolipid biosynthesis (Rattus norvegicus)
Glycosphingolipid biosynthesis (Sus scrofa)
Glycosphingolipid biosynthesis (Xenopus tropicalis)
Authored
Stephan, R (2023-08-17)
Reviewed
D'Eustachio, P (2023-08-17)
D'Eustachio, P (2023-10-24)
Created
Stephan, R (2023-07-17)
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