Reactome | A4GALT transfers galactose to LacCer

A4GALT transfers galactose to LacCer

Stable Identifier

R-HSA-9846477

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Lactosylceramide 4-alpha-galactosyltransferase (globotriaosylceramide (Gb3)/CD77 synthase, A4GALT) transfers a D-alpha-galactose moiety from UDP-alpha-D-galactose onto the 4-position of the beta-galactose residue of lactosylceramide (LacCer) to produce globoside (Gb3Cer). The reaction starts the biosynthesis of globo series glycolipids, which are present on erythrocytes, forming the P1PK blood group system, and may play a role in cancer of other tissues (Kojima et al., 2000; Iwamura et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12888565	The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle Iwamura, K, Urano, T, Furukawa, K, Furukawa, K, Kojima, Y, Uchikawa, M, Sojka, BN, Wiels, J, Shiku, H	J Biol Chem	2003
10748143	Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids Suzuki, Y, Yokoyama, K, Fukumoto, S, Kojima, Y, Wiels, J, Ohta, M, Urano, T, Okajima, T, Furukawa, K, Furukawa, K	J Biol Chem	2000