Reactome | B3GNT5 transfers GlcNAc to LacCer

B3GNT5 transfers GlcNAc to LacCer

Stable Identifier

R-HSA-9846501

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) transfers a N-acetylglucosaminyl (GlcNAc) moiety from UDP-GlcNAc to lactosylceramide, to form lactotriaosylceramide (Lc3Cer), the precursor to lacto- or neolacto-series glycolipids, which are intermediates in the biosynthesis of HNK-1 and Lewis X carbohydrate residues (Togayachi et al., 2001; Togayachi et al., 2010).

Literature References

PubMed ID	Title	Journal	Year
20547865	Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation Togayachi, A, Kozono, Y, Ikehara, Y, Ito, H, Suzuki, N, Tsunoda, Y, Abe, S, Sato, T, Nakamura, K, Suzuki, M, Goda, HM, Ito, M, Kudo, T, Takahashi, S, Narimatsu, H	Proc Natl Acad Sci U S A	2010
11283017	Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids Togayachi, A, Akashima, T, Ookubo, R, Kudo, T, Nishihara, S, Iwasaki, H, Natsume, A, Mio, H, Inokuchi, J, Irimura, T, Sasaki, K, Narimatsu, H	J Biol Chem	2001