Reactome | GAL3ST1 transfers sulfate to GalCer,LacCer

GAL3ST1 transfers sulfate to GalCer,LacCer

Stable Identifier

R-HSA-9844587

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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GAL3ST1 transfers sulfate to GalCer,LacCer

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Galactosylceramide sulfotransferase (GAL3ST1, CST) catalyzes the transfer of sulfate from phosphoadenylylsulfate (PAPS) onto position 3 of beta-galactosyl residues in glycerolipids and sphingolipids yielding sulfogalactoceramide (sulfatide) or sulfo-LacCer (SM3), and adenosine-3',5'-bisphosphate (Honke et al., 1996, 1997). Sulfatides are abundant but not essential in the myelin sheath. GAL3ST1 deficiency leads to the arrest of spermatogenesis. It ameliorates L-selectin-dependent monocyte infiltration in renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin (reviewed by Honke, 2013).

Literature References

PubMed ID	Title	Journal	Year
8830034	Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells Yamane, M, Makita, A, Kobayashi, T, Ishii, A, Honke, K	J Biochem	1996
9030544	Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase Wada, Y, Makita, A, Tsuda, M, Ishii, A, Honke, K, Hirahara, Y	J Biol Chem	1997
23574804	Biosynthesis and biological function of sulfoglycolipids Honke, K	Proc Jpn Acad Ser B Phys Biol Sci	2013