Reactome | FUT1,2 transfer fucose to gangliosides

FUT1,2 transfer fucose to gangliosides

Stable Identifier

R-HSA-9846332

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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Galactoside 2-α-L-fucosyltransferase 1 and 2 (FUT1,2 aka α-1,2-fucosyltransferase 1,2) transfer a fucose (Fuc) sugar to the galactose (Gal) sugar of gangliosides GA1 and GM1 to form FucGA1 and FucGM1, but also the equivalent derivatives of glycoproteins (H antigen; Larsen et al. 1990; Kelly et al., 1995).

Literature References

PubMed ID	Title	Journal	Year
7876235	Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype Kelly, RJ, Rouquier, S, Giorgi, D, Lennon, GG, Lowe, JB	J. Biol. Chem.	1995
2118655	Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen Larsen, RD, Ernst, LK, Nair, RP, Lowe, JB	Proc. Natl. Acad. Sci. U.S.A.	1990