UGT8 transfers Gal from UDP-Gal to CERA

Stable Identifier
R-HSA-6785933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) catalyses the transfer of galactosyl moiety from UDP-galactose (UDP-Gal) to ceramide (CERA), a key step in the biosynthesis of galactocerebrosides (GalCer), which are abundant sphingolipids of the myelin membrane of the CNS and PNS (Kapitonov & Yu 1997, Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
23290777 Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance

Liu, YY, Hill, RA, Li, YT

Adv. Cancer Res. 2013
9125199 Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA

Kapitonov, D, Yu, RK

Biochem. Biophys. Res. Commun. 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylsphingosine galactosyltransferase activity of UGT8 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created
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