UGT8 transfers Gal from UDP-Gal to CERA

Stable Identifier
R-HSA-6785933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8, GCS) catalyzes the transfer of galactosyl moiety from UDP-galactose (UDP-Gal) to ceramide (CERA), an essential step in the biosynthesis of galactocerebrosides (GalCer), which are abundant sphingolipids of the myelin membrane of the CNS and PNS. UGT8 localizes to the luminal part of the endoplasmic reticulum (ER) membrane (Kapitonov & Yu, 1997; Sprong et al., 1998; reviewed by Liu & Li, 2013).
Literature References
PubMed ID Title Journal Year
9125199 Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA

Yu, RK, Kapitonov, D

Biochem. Biophys. Res. Commun. 1997
9748263 UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum

van der Sluijs, P, Sprong, H, Kruithof, B, Leijendekker, R, van Meer, G, Slot, JW

J Biol Chem 1998
23290777 Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance

Liu, YY, Hill, RA, Li, YT

Adv. Cancer Res. 2013
Participants
Participates
Catalyst Activity

N-acylsphingosine galactosyltransferase activity of UGT8 [endoplasmic reticulum membrane]

Orthologous Events
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