Reactome | UGT8 transfers Gal from UDP-Gal to CERA

UGT8 transfers Gal from UDP-Gal to CERA

Stable Identifier

R-HSA-6785933

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8, GCS) catalyzes the transfer of galactosyl moiety from UDP-galactose (UDP-Gal) to ceramide (CERA), an essential step in the biosynthesis of galactocerebrosides (GalCer), which are abundant sphingolipids of the myelin membrane of the CNS and PNS. UGT8 localizes to the luminal part of the endoplasmic reticulum (ER) membrane (Kapitonov & Yu, 1997; Sprong et al., 1998; reviewed by Liu & Li, 2013).

Literature References

PubMed ID	Title	Journal	Year
9125199	Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA Kapitonov, D, Yu, RK	Biochem. Biophys. Res. Commun.	1997
9748263	UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum Sprong, H, Kruithof, B, Leijendekker, R, Slot, JW, van Meer, G, van der Sluijs, P	J Biol Chem	1998
23290777	Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Liu, YY, Hill, RA, Li, YT	Adv. Cancer Res.	2013