Reactome | ST6GALNAC5,6 transfer Neu5Ac to GM1b

ST6GALNAC5,6 transfer Neu5Ac to GM1b

Stable Identifier

R-HSA-9846305

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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Alpha-2,6-sialyltransferases 5 and 6 (ST6GALNAC5,6) transfer a sialic acid (Neu5Ac) moiety to the terminal N-acetylgalactosaminyl (GalNAc) residue of ganglioside GM1b to produce ganglioside GD1alpha (GD1α). Neu5Ac is added to GalNAc-R via an alpha-2,6 linkage (Ikehara et al. 1999, Tsuchida et al. 2003). To date, the specific function of α-series gangliosides is poorly understood.

Literature References

PubMed ID	Title	Journal	Year
10601645	A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1) Kono, M, Ikehara, Y, Nakanishi, H, Shimizu, N, Tatematsu, M, Kitamura, T, Tsuji, S, Narimatsu, H, Nishihara, S	FEBS Lett	1999
12668675	Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides Yoshida, A, Furukawa, K, Nakamura, Y, Tsuchida, A, Okajima, T, Furukawa, K, Ando, T, Kannagi, R, Ishida, H, Kiso, M	J. Biol. Chem.	2003