Reactome | ST6GALNAC5,6 transfer Neu5Ac to GM1b

ST6GALNAC5,6 transfer Neu5Ac to GM1b

Stable Identifier

R-HSA-9846305

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Alpha-2,6-sialyltransferases 5 and 6 (ST6GALNAC5,6) transfer a sialic acid (Neu5Ac) moiety to the terminal N-acetylgalactosaminyl (GalNAc) residue of ganglioside GM1b to produce ganglioside GD1alpha (GD1α). Neu5Ac is added to GalNAc-R via an alpha-2,6 linkage (Ikehara et al. 1999, Tsuchida et al. 2003). To date, the specific function of α-series gangliosides is poorly understood.

Literature References

PubMed ID	Title	Journal	Year
10601645	A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1) Ikehara, Y, Shimizu, N, Kono, M, Nishihara, S, Nakanishi, H, Kitamura, T, Narimatsu, H, Tsuji, S, Tatematsu, M	FEBS Lett	1999
12668675	Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides Tsuchida, A, Okajima, T, Furukawa, K, Ando, T, Ishida, H, Yoshida, A, Nakamura, Y, Kannagi, R, Kiso, M, Furukawa, K	J. Biol. Chem.	2003