Reactome | UGCG transfers glucose to ceramide

UGCG transfers glucose to ceramide

Stable Identifier

R-HSA-1638104

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Ceramide glucosyltransferase (UGCG, CGT, GCS) catalyzes the first glycosylation step in glycosphingolipid biosynthesis by transferring glucose to ceramide (Ichikawa et al. 1996). UGCG is localized on the cytosolic part of the cis-Golgi membrane. The cytosolic PLEKHA8 (FAPP2) will transport the product GlcCer to the plasma membrane. GlcCer is also transported to the inside of the Golgi membrane by MDR1 ("flipping"; Fabiana de Rosa et al., 2004; Eckford & Sharom, 2005; reviewed by Liu & Li, 2013).

Literature References

PubMed ID	Title	Journal	Year
8643456	Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis Ichikawa, S, Sakiyama, H, Suzuki, G, Hidari, KI, Hirabayashi, Y	Proc Natl Acad Sci U S A	1996
23290777	Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Liu, YY, Hill, RA, Li, YT	Adv. Cancer Res.	2013
15799713	The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids Eckford, PD, Sharom, FJ	Biochem J	2005
14662772	Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis De Rosa, MF, Sillence, D, Ackerley, C, Lingwood, C	J Biol Chem	2004