Reactome | B4GALT5/6 transfer Gal to GlcCer

B4GALT5/6 transfer Gal to GlcCer

Stable Identifier

R-HSA-9851347

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Beta-1,4-galactosyltransferases 5 and 6 (B4GALT5/6) catalyze the transfer of galactose from UDP-α-D-galactose onto glucosylceramide (GlcCer) to produce lactosylceramide (LacCer). LacCer is the primary precursor in the biosynthesis of complex glycosphingolipids (Tokuda et al., 2013; Yamaji & Hanada, 2014; reviewed by Chatterjee et al., 2021).

Literature References

PubMed ID	Title	Journal	Year
33673027	Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes Chatterjee, S, Balram, A, Li, W	Int J Mol Sci	2021
23882130	β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5 Tokuda, N, Numata, S, Li, X, Nomura, T, Takizawa, M, Kondo, Y, Yamashita, Y, Hashimoto, N, Kiyono, T, Urano, T, Furukawa, K, Furukawa, K	Glycobiology	2013
24498430	Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs Yamaji, T, Hanada, K	PLoS One	2014