Reactome | B3GALT4 transfers Gal to gangliosides

B3GALT4 transfers Gal to gangliosides

Stable Identifier

R-HSA-9845516

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Beta-1,3-galactosyltransferase 4 (B3GALT4) transfers galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of the beta-N-acetylglucosamine (β-GlcNAc) residue on gangliosides GM2/GD2/GA2 to form gangliosides GM1/GD1b/GA1 (Amado et al., 1998; reviewed in Hennet, 2002).

Literature References

PubMed ID	Title	Journal	Year
12222957	The galactosyltransferase family Hennet, T	Cell. Mol. Life Sci.	2002
9582303	A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family Holmes, EH, Almeida, R, Bennett, EP, Nomoto, M, Amado, M, Hassan, H, Carneiro, F, Schwientek, T, Hollingsworth, MA, Nielsen, PA, Levery, SB, Clausen, H	J Biol Chem	1998