Reactome | ST8SIA5 transfers Neu5Ac to gangliosides

ST8SIA5 transfers Neu5Ac to gangliosides

Stable Identifier

R-HSA-9845587

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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ST8SIA5 transfers Neu5Ac to gangliosides

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Alpha-2,8-sialyltransferase 5 (ST8SIA5) transfers N-acetylneuraminate (Neu5Ac) to terminal Neu5Ac-yl groups of gangliosides GD1a, GT1b, GM1b and GD3 to produce gangliosides GD1c, GT1a, GQ1b, and GP1c (Kono et al., 1996; Kim et al. 1997). Gangliosides localize to the plasma membrane via vesicle transport, endocytosis, and exocytosis. Three isoforms of ST8SIA5 may have different localizations and substrate specificities (Araki et al., 2022).

Literature References

PubMed ID	Title	Journal	Year
9199191	Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V) Do, S, Kim, KS, Kim, YJ, Lee, YC, Kim, SK, Kim, CH	Biochem. Biophys. Res. Commun.	1997
34982351	Analysis of biochemical features of ST8 α-N-acetyl-neuraminide α2,8-sialyltransferase (St8sia) 5 isoforms Kimura, R, Konishi, M, Komura, N, Kitajima, K, Tsuda, K, Araki, E, Sato, C, Ando, H, Hatanaka, R, Hane, M	Glycoconj J	2022
8910600	Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3 Kono, M, Kojima, N, Yoshida, Y, Tsuji, S	J Biol Chem	1996