CERK phosphorylates CERA to form C1P

Stable Identifier
R-HSA-1638845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Ceramide kinase (CERK) mediates the phosphorylation of ceramide
ReviewStatus
5/5
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Ceramide kinase (CERK) mediates the phosphorylation of ceramide (CERA) to the lipid second messenger, ceramide 1-phosphate (C1P). Although Cer species with N>12 carbon chains are better substrates, short-chain Cer species, including C2-Cer, can also be reacted. CERK is located in the plasma membrane, with CERA being supplied both by transporters from de-novo biosynthesis in the Golgi or by the hydrolysis of sphingomyelin in the plasma membrane (Sugiura et al. 2002; reviewed in Bornancin, 2011). The product C1P is involved in cancer cell growth, migration, survival, and inflammation (reviewed by Hait & Maiti, 2017).
Literature References
PubMed ID Title Journal Year
11956206 Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

Liu, H, Sugiura, M, Kohama, T, Spiegel, S, Kono, K, Shimizugawa, T, Minekura, H

J Biol Chem 2002
21111813 Ceramide kinase: the first decade

Bornancin, F

Cell Signal 2011
29269995 The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Hait, NC, Maiti, A

Mediators Inflamm 2017
Participants
Participates
Catalyst Activity

ceramide kinase activity of CERK [plasma membrane]

Orthologous Events
Authored
Reviewed
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