Reactome | CERK phosphorylates CERA to form C1P

CERK phosphorylates CERA to form C1P

Stable Identifier

R-HSA-1638845

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

Ceramide kinase (CERK) mediates the phosphorylation of ceramide

ReviewStatus

5/5

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Ceramide kinase (CERK) mediates the phosphorylation of ceramide (CERA) to the lipid second messenger, ceramide 1-phosphate (C1P). Although Cer species with N>12 carbon chains are better substrates, short-chain Cer species, including C2-Cer, can also be reacted. CERK is located in the plasma membrane, with CERA being supplied both by transporters from de-novo biosynthesis in the Golgi or by the hydrolysis of sphingomyelin in the plasma membrane (Sugiura et al. 2002; reviewed in Bornancin, 2011). The product C1P is involved in cancer cell growth, migration, survival, and inflammation (reviewed by Hait & Maiti, 2017).

Literature References

PubMed ID	Title	Journal	Year
11956206	Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization Sugiura, M, Kono, K, Liu, H, Shimizugawa, T, Minekura, H, Spiegel, S, Kohama, T	J Biol Chem	2002
21111813	Ceramide kinase: the first decade Bornancin, F	Cell Signal	2011
29269995	The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer Hait, NC, Maiti, A	Mediators Inflamm	2017