CERK phosphorylates CERA to form C1P

Stable Identifier
R-HSA-1638845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
Ceramide kinase (CERK) mediates the phosphorylation of ceramide
ReviewStatus
5/5
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CERK phosphorylates CERA to form C1P
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Ceramide kinase (CERK) mediates the phosphorylation of ceramide (CERA) to the lipid second messenger, ceramide 1-phosphate (C1P) (Sugiura et al. 2002).

Literature References
PubMed ID Title Journal Year
11956206 Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

Liu, H, Sugiura, M, Kohama, T, Spiegel, S, Kono, K, Shimizugawa, T, Minekura, H

J Biol Chem 2002
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Output
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as an event of
Catalyst Activity

ceramide kinase activity of CERK [plasma membrane]

Physical Entity
CERK [plasma membrane] (Homo sapiens)
Activity
ceramide kinase activity (GO:0001729)
Orthologous Events
CERK phosphorylates CERA to form C1P (Bos taurus)
CERK phosphorylates CERA to form C1P (Caenorhabditis elegans)
CERK phosphorylates CERA to form C1P (Canis familiaris)
CERK phosphorylates CERA to form C1P (Danio rerio)
CERK phosphorylates CERA to form C1P (Drosophila melanogaster)
CERK phosphorylates CERA to form C1P (Gallus gallus)
CERK phosphorylates CERA to form C1P (Mus musculus)
CERK phosphorylates CERA to form C1P (Rattus norvegicus)
CERK phosphorylates CERA to form C1P (Sus scrofa)
CERK phosphorylates CERA to form C1P (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-10)
Reviewed
Stephan, R  (2011-10-31)
Created
Jassal, B  (2011-10-10)
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