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DICER1 [cytosol]
Stable Identifier
R-HSA-203820
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
MicroRNA (miRNA) biogenesis (Homo sapiens)
Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA RLC [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA RLC:duplex miRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4:duplex miRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex:duplex miRNA [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Duplex miRNA is loaded into Argonaute (Homo sapiens)
TARBP2,PRKRA RLC:duplex miRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4:duplex miRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex:duplex miRNA [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Removal of miRNA passenger strand (Homo sapiens)
TARBP2,PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA:DICER1:RISC (miRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:RISC (miRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Small interfering RNA (siRNA) biogenesis (Homo sapiens)
Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA RLC [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex:duplex siRNA [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Duplex siRNA is loaded into Argonaute (Homo sapiens)
TARBP2,PRKRA RLC:duplex siRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4:duplex siRNA [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
RISC loading complex:duplex siRNA [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
Removal of siRNA passenger strand (Homo sapiens)
TARBP2,PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2,PRKRA:DICER1:RISC (siRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
TARBP2:DICER1:RISC (siRNA) [cytosol] (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis (Homo sapiens)
DICER1 cleaves tRNA (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)
DICER1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPY3 DICER1
Gene Names
DICER1, DICER, HERNA, KIAA0928
Chain
chain:1-1922
Reference Genes
BioGPS Gene:23405 DICER1
COSMIC (genes):DICER1 DICER1
CTD Gene:23405 DICER1
dbSNP Gene:23405 DICER1
ENSEMBL:ENSG00000100697 DICER1
ENSEMBL_homo_sapiens_GENE:ENSG00000100697.17 DICER1
HGNC:17098 DICER1
KEGG Gene (Homo sapiens):23405 DICER1
Monarch:23405 DICER1
NCBI Gene:23405 DICER1
OMIM:606241 DICER1
UCSC:Q9UPY3 DICER1
Reference Transcript
RefSeq:NM_177438.2 DICER1
RefSeq:XM_011536601.2 DICER1
RefSeq:XM_017021121.1 DICER1
RefSeq:NM_001271282.2 DICER1
RefSeq:NM_001195573.1 DICER1
RefSeq:XM_011536600.2 DICER1
RefSeq:XM_017021120.1 DICER1
RefSeq:NM_030621.4 DICER1
RefSeq:XM_011536602.2 DICER1
RefSeq:NM_001291628.1 DICER1
RefSeq:XM_011536599.1 DICER1
Other Identifiers
11719525_s_at
11740190_s_at
11755211_a_at
11757970_s_at
16796325
206061_PM_s_at
206061_s_at
212888_PM_at
212888_at
213229_PM_at
213229_at
23405
2813042
2813044
3577869
3577871
3577872
3577873
3577874
3577875
3577876
3577878
3577879
3577882
3577884
3577885
3577886
3577890
3577891
3577892
3577893
3577894
3577895
3577896
3577898
3577899
3577901
3577902
3577905
3577906
3577907
3577909
3577910
3577911
3577915
3577916
3577917
3577918
3577920
3577921
3577922
3577923
3577925
3577928
3577929
3577933
3577934
3577935
38764_at
38765_at
7981111
A_23_P37111
A_24_P22163
A_33_P3212490
GE53691
GO:0000122
GO:0000166
GO:0003677
GO:0003723
GO:0003725
GO:0003824
GO:0004386
GO:0004518
GO:0004519
GO:0004521
GO:0004525
GO:0004530
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0006309
GO:0006351
GO:0006355
GO:0006396
GO:0006399
GO:0010586
GO:0010626
GO:0010629
GO:0012501
GO:0014040
GO:0016078
GO:0016442
GO:0016787
GO:0016891
GO:0019904
GO:0021675
GO:0023052
GO:0030154
GO:0030422
GO:0031047
GO:0031054
GO:0031643
GO:0032290
GO:0032720
GO:0035196
GO:0035197
GO:0038061
GO:0043226
GO:0046872
GO:0048471
GO:0048812
GO:0048856
GO:0050877
GO:0065003
GO:0070062
GO:0070578
GO:0070883
GO:0070922
GO:0090501
GO:0090502
GO:0098795
GO:0140097
GO:0140098
GO:0140657
HMNXSV003038678
Hs.325625.0.A1_3p_at
Hs.87889.1.A1_3p_a_at
ILMN_1686725
ILMN_1706100
ILMN_1772692
ILMN_2349831
PH_hs_0004928
TC14001472.hg
TC14002137.hg
p33860
Participates
as a component of
PRKRA:DICER1:RISC (miRNA) [cytosol] (Homo sapiens)
TARBP2:DICER1:RISC (miRNA) [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (miRNA) [cytosol] (Homo sapiens)
TARBP2:DICER1:RISC (siRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:RISC (siRNA) [cytosol] (Homo sapiens)
PRKRA:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
TARBP2:DICER1:Pre-RISC (siRNA) [cytosol] (Homo sapiens)
RISC loading complex [cytosol] (Homo sapiens)
PRKRA:DICER1:AGO1,2,3,4 [cytosol] (Homo sapiens)
Inferred To
DICER1 [cytosol]
(Bos taurus)
DICER1 [cytosol]
(Caenorhabditis elegans)
DICER1 [cytosol]
(Canis familiaris)
DICER1 [cytosol]
(Drosophila melanogaster)
DICER1 [cytosol]
(Gallus gallus)
DICER1 [cytosol]
(Mus musculus)
DICER1 [cytosol]
(Sus scrofa)
DICER1 [cytosol]
(Xenopus tropicalis)
Dicer1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_803187.1
,
XP_011534904.1
,
XP_016876610.1
,
XP_011534903.1
,
XP_016876609.1
,
NP_001182502.1
,
NP_001278557.1
,
NP_001258211.1
,
XP_011534902.1
,
NP_085124.2
,
XP_011534901.1
OpenTargets
ENSG00000100697
IntEnz
3.1.26.3
HPA
ENSG00000100697-DICER1
GeneCards
Q9UPY3
Ensembl
ENSP00000437256
,
ENSP00000435681
,
ENST00000674628
,
ENST00000526495
,
ENST00000393063
,
ENST00000529720
,
ENST00000527414
,
ENSP00000433926
,
ENSG00000100697
,
ENST00000343455
,
ENSP00000502730
,
ENSP00000376783
,
ENST00000541352
,
ENSP00000433060
,
ENST00000531162
,
ENSP00000444719
,
ENSP00000343745
PRO
Q9UPY3
Pharos - Targets
Q9UPY3
Orphanet
18649
PDB
4NGB
,
4NGC
,
5ZAM
,
4NH3
,
4NHA
,
4NGD
,
7XW2
,
4NGF
,
4NH5
,
5ZAK
,
4NH6
,
5ZAL
,
2EB1
,
4WYQ
,
7XW3
,
4NGG
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15633 TARBP2
2
TARBP2 [cytosol]
(R-HSA-203864)
p-TARBP2 [cytosol]
(R-HSA-9835348)
0.956
25
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.942
20
UniProt:O75569 PRKRA
2
p-S246,S287-PRKRA [cytosol]
(R-HSA-9834791)
PRKRA [cytosol]
(R-HSA-2399897)
0.743
8
UniProt:Q9UL18 AGO1
2
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
EIF2C1 [cytosol]
(R-HSA-210616)
0.723
5
UniProt:P55265-5 ADAR
0.653
8
UniProt:P0C205 REX
0.61
7
UniProt:P55265-1 ADAR
0.591
4
IntAct:EBI-11169796 PRE-HSA-MIR-34C
0.544
3
IntAct:EBI-11169820 PRE
0.544
3
IntAct:EBI-11169865 PRE
0.544
3
IntAct:EBI-2938324 PRE-LET-7A-1
0.544
3
IntAct:EBI-11169630 PRE-HSA-MIR-200A
0.544
2
UniProt:O43508 TNFSF12
2
TNFSF12 [plasma membrane]
(R-HSA-5667154)
sTNFSF12 [extracellular region]
(R-HSA-5675974)
0.543
3
UniProt:O60506 HNRPQ
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
2
UniProt:Q8CJG0 Ago2
3
AGO2 [nucleoplasm]
(R-MMU-5578701)
Ago2 [cytosol]
(R-MMU-9621518)
AGO2 [cytosol]
(R-MMU-209723)
0.524
2
UniProt:Q9Y6A4 CFA20
0.508
2
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.504
3
UniProt:Q9IK90 MATRX
0.499
3
UniProt:Q96J94 PIWIL1
1
4xMeR-PIWIL1 [cytosol]
(R-HSA-5601891)
0.499
2
UniProt:Q96C10 DHX58
1
DHX58 [cytosol]
(R-HSA-913540)
0.499
2
UniProt:P19525 EIF2AK2
5
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
EIF2AK2 [cytosol]
(R-HSA-168699)
0.499
2
UniProt:Q96DB2 HDAC11
1
HDAC11 [nucleoplasm]
(R-HSA-351590)
0.462
3
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