Reactome | RABEP1 [early endosome membrane]

RABEP1 [early endosome membrane]

Stable Identifier

R-HSA-2029004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Rabaptin, Rab GTPase-binding effector protein 1, RABE1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15276 RABEP1

Gene Names

RABEP1, RAB5EP, RABPT5, RABPT5A

Chain

initiator methionine:, chain:2-862

Reference Genes

BioGPS Gene:9135 RABEP1

COSMIC (genes):RABEP1 RABEP1

CTD Gene:9135 RABEP1

dbSNP Gene:9135 RABEP1

ENSEMBL:ENSG00000029725 RABEP1

HGNC:17677 RABEP1

Monarch:9135 RABEP1

NCBI Gene:9135 RABEP1

OMIM:603616 RABEP1

UCSC:Q15276 RABEP1

Reference Transcript

Other Identifiers

11718614_s_at

11718615_a_at

11718616_s_at

11748594_a_at

16830103

203223_PM_at

203223_at

214552_PM_s_at

214552_s_at

225064_PM_at

225064_at

225092_PM_at

225092_at

231002_PM_s_at

231002_s_at

32741_at

32742_s_at

3630845

3707643

3707644

3707645

3707650

3707653

3707655

3707657

3707659

3707667

3707668

3707670

3707671

3707672

3707673

3707674

3707676

3707677

3707678

3707681

3707682

3707683

3707684

3707686

3707687

3707688

3707689

3707690

3707691

3707692

3707693

3707706

8004111

9135

A_23_P78158

A_24_P399174

A_24_P945147

A_32_P142013

A_33_P3275998

GE79964

GO:0005096

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0006893

GO:0006897

GO:0006915

GO:0007165

GO:0008083

GO:0012501

GO:0015031

GO:0016192

GO:0019904

GO:0030139

GO:0031410

GO:0031901

GO:0032991

GO:0042803

GO:0043226

GO:0043231

GO:0048018

GO:0055037

GO:0061024

GO:0061025

GO:0098772

GO:0098978

GO:0099149

GO:1903441

HMNXSV003033619

Hs.172108.3.A1_3p_at

Hs.250535.1.A1_3p_at

Hs.250535.1.A2_3p_at

Hs.326056.1.S1_3p_a_at

ILMN_1719622

PH_hs_0024519

PH_hs_0031990

TC17000065.hg

X91141_at

Participates

as a component of

GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)

Inferred To

rabn-5 [early endosome membrane] (Caenorhabditis elegans)

RABEP1 [early endosome membrane] (Gallus gallus)

RABEP1 [early endosome membrane] (Sus scrofa)

Ghost homologue of RABEP1 [early endosome membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000341923, ENSP00000339569, ENST00000537505, ENSP00000445408

OpenTargets

ENSG00000029725

HPA

ENSG00000029725-RABEP1

PRO

Q15276

Pharos - Targets

Q15276

HMDB Protein

HMDBP08512

PDB

4Q9U, 4N3Z, 4N3Y, 1P4U, 1TU3, 1X79

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.698	12
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.643	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	3
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P49675 STAR	2	STAR [mitochondrial matrix] (R-HSA-9838092) STAR [mitochondrial intermembrane space] (R-HSA-196120)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.527	2
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.508	2
UniProt:O75843 AP1G2	1	AP1G2 [Golgi membrane] (R-HSA-5216197)	0.508	2