Reactome | BARD1 [nucleoplasm]

BARD1 [nucleoplasm]

Stable Identifier

R-SSC-9701024

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

K6PolyUb-BARD1, A0A5G2RET1

Locations in the PathwayBrowser

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DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - DNA Double Strand Break Response (Sus scrofa)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Sus scrofa)
      - BRCA1:BARD1 heterodimer autoubiquitinates (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
      - Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)
        
        BRCA1:BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Sus scrofa)
        
        BRCA1-A Complex [nucleoplasm] (Sus scrofa)
        
        BRCA1:BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Sus scrofa)
        
        BRCA1-A Complex [nucleoplasm] (Sus scrofa)
        
        BRCA1:BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
      - UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
        
        UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - Metalloprotease DUBs (Sus scrofa)
      - BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)
        
        BRCA1-A Complex:Histone H2A [nucleoplasm] (Sus scrofa)
        
        BRCA1-A Complex [nucleoplasm] (Sus scrofa)
        
        BRCA1:BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)
        
        BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Sus scrofa)
        
        BRCA1-A Complex [nucleoplasm] (Sus scrofa)
        
        BRCA1:BARD1 [nucleoplasm] (Sus scrofa)
        
        K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)
        
        BARD1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RET1

Gene Names

BARD1

Reference Genes

BioGPS Gene:100511662 BARD1

ENSEMBL:ENSSSCG00000016170.5

KEGG:ssc:100511662 BARD1

Monarch:100511662 BARD1

NCBI Gene:100511662 BARD1

UCSC:A0A5G2RET1 BARD1

Reference Transcript

RefSeq:XM_021075146.1 BARD1

Other Identifiers

100511662

GO:0000152

GO:0003677

GO:0003697

GO:0003723

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006301

GO:0006513

GO:0006974

GO:0008270

GO:0016607

GO:0016740

GO:0031436

GO:0036464

GO:0042803

GO:0043065

GO:0043066

GO:0043226

GO:0046826

GO:0046872

GO:0046982

GO:0061630

GO:0070531

GO:0070532

GO:0070533

GO:0071479

GO:0085020

GO:0140096

Participates

as a component of

K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Sus scrofa)

Other forms of this molecule

BARD1 [nucleoplasm]

phospho-BARD1 [nucleoplasm]

Inferred From

K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K6-PolyUb [nucleoplasm]) at unknown position

Modification

K6polyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_020930805.1

ENSEMBL

ENSSSCP00000069422, ENSSSCT00000075204, ENSSSCG00000016170

VGNC

96509